Basic Information

Symbol
hsa-mir-376a-2
RNA class
miRNA miRNA hairpin
Alias
MIR376A2 MicroRNA 376a-2 Hsa-MiR-376a-3p Hsa-Mir-376a-2 MIRN376A2 Hsa-Mir-376-P3_pre Hsa-MiR-376a-2-5p MIMAT0022928 MIMAT0000729 MIRN376A-2 Mir-376a-2 MIR376A-2 MI0003529
Location (GRCh38)
14:101040069-101040148
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-376a-2
Sequence length
80 nt
GC content
0.3375

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-29.00 kcal/mol
Thermodynamic ensemble
Free energy: -30.18 kcal/mol
Frequency: 0.1483
Diversity: 4.74
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
((((((.((((.((.(((((((({{((((((((((((.....)))..)))))))))))))))))).)).)))).))))))
Forensic Context

A study in mice demonstrated that the mir-376a is upregulated in serum at 3 hours post-mild traumatic brain injury across injury severities, identifying it as a potential biomarker for mild TBI [Martinez & Peplow DOI:10.4103/1673-5374.219025]. A systematic review and meta-analysis in humans reported the mir-376a as a diagnostic marker for severe TBI from cerebellar tissue, contributing to the overall high diagnostic accuracy of miRNAs for TBI [Zhou et al. DOI:10.7150/ijms.48214].