Basic Information

Symbol
hsa-mir-376c
RNA class
miRNA miRNA hairpin
Alias
MIR376C MicroRNA 376c Hsa-MiR-376c-3p Hsa-Mir-376c Hsa-Mir-368 MicroRNA 368 MIRN376C MIRN368 Hsa-Mir-376-P4_pre Hsa-MiR-376c-5p MIMAT0022861 MIMAT0000720 MI0000776 MiRNA368 Mir-376c MIR368
Location (GRCh38)
14:101039690-101039755
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Sudden death from CNS diseases
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-376c
Sequence length
66 nt
GC content
0.2879

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-24.90 kcal/mol
Thermodynamic ensemble
Free energy: -26.19 kcal/mol
Frequency: 0.1230
Diversity: 4.48
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((.(((((..(((((.(((((((((.............))))))))))))))..))))).))))
Thermodynamic Ensemble Prediction
{(((.(((((..(((({{(((((((((.............))))))))))))))..))))).)))}
Forensic Context

A study in human full-term newborns demonstrated that the mir-376c has lower levels reported in newborns with hypoxic-ischemic encephalopathy, as mentioned in the introductory literature [Lai et al. DOI:10.1016/j.pedneo.2024.05.002]. In a separate study of human left ventricular myocardium, the mir-376c was identified as one of the most abundant miRNAs in baseline and postischemic samples, and it was downregulated (-2.75 fold) in postischemic tissue following acute ischemia [Saddic et al. DOI:10.1152/physiolgenomics.00049.2015].