Basic Information

Symbol
hsa-mir-378a
RNA class
miRNA miRNA hairpin
Alias
MIR378A MicroRNA 378a Hsa-MiR-378a-3p Hsa-MiR-378a-5p Hsa-Mir-378 MicroRNA 378 MIRN378 MIR378 Hsa-Mir-378_pre Hsa-Mir-378a MIMAT0000732 MIMAT0000731 MI0000786 MiRNA378
Location (GRCh38)
5:149732825-149732890
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-378a
Sequence length
66 nt
GC content
0.5303

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-38.50 kcal/mol
Thermodynamic ensemble
Free energy: -39.63 kcal/mol
Frequency: 0.1598
Diversity: 10.56
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((.((.((((((((((((((.((((..(........)..)))).)))))))))))))).)).)))
Thermodynamic Ensemble Prediction
,((,((.((((((((((((((.({((,,(,.......},,)))).)))))))))))))).}).)))
Forensic Context

A study in humans demonstrated that the mir-378a was selected as a vaginal secretion-specific candidate but did not show conspicuous specificity across five tested body fluids (peripheral blood, menstrual blood, semen, saliva, vaginal secretion) in the experiment, though it still contributed to body fluid prediction within a probabilistic model [Li et al. DOI:10.1007/s00414-021-02678-w]. A study in mice demonstrated that plasma exosomes isolated one day after traumatic brain injury (TBI) combined with a tibial fracture contained highly expressed miRNAs, including the mir-378a, which promoted osteoblast proliferation and differentiation in vitro, leading to enhanced matrix mineralization and accelerated bone healing in vivo [Yang et al. DOI:10.1016/j.jot.2021.09.003].