Basic Information

Symbol
hsa-miR-378c
RNA class
miRNA mature miRNA
Alias
hsa-miR-378c MIR378C MicroRNA 378c
Location (GRCh38)
-
Forensic tag(s)
Mechanical injury analysis Wound age identification Drug abuse diagnoses
External database
miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-miR-378c
Sequence length
25 nt
GC content
0.5200

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-36.70 kcal/mol
Thermodynamic ensemble
Free energy: -38.53 kcal/mol
Frequency: 0.1938
Diversity: 3.93
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in mice demonstrated that plasma exosomes after traumatic brain injury (TBI) promote osteoblast proliferation and differentiation, with the miR-378c being highly expressed in these exosomes [Yang et al. DOI:10.1016/j.jot.2021.09.003]. In human skin, the miR-378c was found to be downregulated four days post-burn in deep partial thickness burn skin compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. In a separate investigation in mice, the miR-378c was significantly downregulated in the nucleus accumbens of methamphetamine-sensitized animals, while its precursor showed no significant change, indicating a post-transcriptional regulatory mechanism involving the downregulation of Ago2 [Liu et al. DOI:10.1111/Adb.12616].