Forensic Context

A study in humans demonstrated that the miR-379-5p was significantly decreased in pericardial-fluid-derived exosomes from acute myocardial infarction patients compared to controls [Kim et al. DOI:10.3390/ijms25179619], while a separate review of human skin studies reported that the miR-379-5p was upregulated in burn hypertrophic scar tissue and its derived fibroblasts compared to normal tissue [Siu et al. DOI:10.1111/wrr.13100]. A study in rats demonstrated that the miR-379-5p is downregulated in the infralimbic prefrontal cortex after a 4-week abstinence from escalated cocaine self-administration [Kumaresan et al. DOI:10.3390/Biomedicines11051368]. In a separate rat model of burn-induced acute lung injury, the miR-379-5p was found to be upregulated in lung tissue at 24 hours post-injury [Zhang et al. DOI:10.5505/tjtes.2018.98123].