Basic Information

Symbol
hsa-mir-1227
RNA class
miRNA miRNA hairpin
Alias
MIR1227 MicroRNA 1227 Hsa-Mir-1227 Hsa-MiR-1227-3p MIRN1227 Hsa-MiR-1227-5p MIMAT0022941 MIMAT0005580 MI0006316 Mir-1227
Location (GRCh38)
5:154347106-154347247
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-1227
Sequence length
88 nt
GC content
0.6932

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-38.60 kcal/mol
Thermodynamic ensemble
Free energy: -40.24 kcal/mol
Frequency: 0.0700
Diversity: 27.85
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((..(((.((((((.....((((..((.((.......)).))..)))).(((((........))))))))))))))..))))).
Thermodynamic Ensemble Prediction
.(((((..(((.((((((..{{,((((|,((,((..,.,.,}}.}}.,)),,.||(((.....,.,))}}})))))))))..))))).
Forensic Context

A study in humans identified the mir-1227-3p as a diagnostic biomarker for acute myocardial infarction (AMI) and coronary artery disease (CAD), where it was upregulated in the CAD group compared to the AMI group and was part of an 18-exosomal-miRNA panel that achieved an area under the curve (AUC) of 0.75 for CAD detection [Guo et al. DOI:10.21037/atm-20-2337].