Basic Information

Symbol
hsa-mir-381
RNA class
miRNA miRNA hairpin
Alias
MIR381 MicroRNA 381 Hsa-Mir-381 Hsa-MiR-381-3p MIRN381 Hsa-Mir-154-P9_pre Hsa-MiR-381-5p MIMAT0000736 MIMAT0022862 MI0000789 Mir-381
Location (GRCh38)
14:101045920-101045994
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-381
Sequence length
75 nt
GC content
0.4000

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-35.50 kcal/mol
Thermodynamic ensemble
Free energy: -36.92 kcal/mol
Frequency: 0.1005
Diversity: 5.05
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((.((.(((.((((((((.((((((((.((........)).)))))))))))))))).))).)).))))))
Thermodynamic Ensemble Prediction
((((((.((.(((.(((((({{{((((((((.((........)).)))))))))))))))).))).)).))))))
Forensic Context

A study in humans demonstrated that serum levels of the mir-381 were significantly upregulated in patients with mild traumatic brain injury (mTBI) at baseline compared to controls, with a progressive reduction at 24 and 48 hours post-injury, and it was also differentially expressed between mTBI patients and those with other injuries, identifying it as a sensitive and specific biomarker useful for monitoring the post-trauma period [Polito et al. DOI:10.1007/s11033-020-05386-7].