Basic Information
Symbol
hsa-miR-384
RNA class
miRNA
mature miRNA
Alias
hsa-miR-384
MIR384
MicroRNA 384
Location (GRCh38)
-
Forensic tag(s)
Cause of death analysis
Sudden death from CNS diseases
Drug abuse diagnoses
External database
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-14.90 kcal/mol
Thermodynamic ensemble
Free energy:
-17.37 kcal/mol
Frequency:
0.0180
Diversity:
11.52
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
{((((...((((.{((...(((((((.(((({{..{(((.........}})}.}},....)))).)))))))...))}.))))))))}
Forensic Context
A study in full-term human newborns demonstrated that the miR-384 was downregulated in plasma at 0–6 hours after birth in cases of perinatal asphyxia compared to healthy controls, as identified via next-generation sequencing [Lai et al. DOI:10.1016/j.pedneo.2024.05.002]. A systematic review of substance abuse literature reported that the miR-384 is downregulated in the peripheral blood of newborns with hypoxic-ischemic encephalopathy and is also downregulated following acute cocaine use in an Ago2-dependent manner, playing a role in neural plasticity and motivation [Occhipinti et al. DOI:10.3390/Ijms242317122].