Forensic Context

A review of human studies found that the miR-409-3p is downregulated 24 hours post-injury in skin wounds compared to unwounded skin [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the miR-409-3p was upregulated in liver tissue following whole-body ionizing radiation exposure, with a log2 fold change of 1.19, as identified via high-throughput deep sequencing and validated by consistent qRT-PCR results [Lu et al. DOI:10.1002/cbin.10627]. In human monozygotic twins, longitudinal analysis over eight years identified the miR-409-3p as a significant predictor of age-related functional decline, where a higher baseline plasma level was associated with improved physical functionality over time, as indicated by a positive beta coefficient [La Grotta et al. DOI:10.1016/j.mad.2025.112099].