Basic Information

Symbol
COX14
RNA class
mRNA
Alias
Cytochrome C Oxidase Assembly Factor COX14 C12orf62 COX14, Cytochrome C Oxidase Assembly Factor Cytochrome C Oxidase Assembly Protein COX14 MGC14288 COX14 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae) COX14 Cytochrome C Oxidase Assembly Homolog Cytochrome C Oxidase Assembly Homolog 14 Chromosome 12 Open Reading Frame 62 MC4DN10 PCAG1
Location (GRCh38)
12:50112082-50120457
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_032901.4
Sequence length
484.0 nt
GC content
0.5248

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-162.00 kcal/mol
Thermodynamic ensemble
Free energy: -172.06 kcal/mol
Frequency: 0.0000
Diversity: 90.12
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((((...((((((..((((....))))(((((.....((((.(((((((((.....((((.((........))..))))...))))))((((......))))...(((.....))).(((((((.((((........)))))))))))...))).))))....)))))....(((((......))))).)))))).....))..))))))).......((((((.((((........(((.((((((((((.((((((((....)).)))))).)))..((((.(..((((((...)))))))))))(((.......)))...(((((((((((...(.(((((((((....((....))..)))))...)))).)...)))))))))))))))))).))).......)))))))))).......((((((((.((.(((((.....))))).)).)...........)))))))...
Thermodynamic Ensemble Prediction
.(((((((((.{.((((((..((((....))))(((((.....((((.((({(((((.....((((.((.{,...,}))..))))...)))))|((((,....,))))...,{,...,,}.|{((((({{.((((........))))}}}))))}},))).))))....)))))....(((((......))))).)))))).,...))..)))))))....,,.((((((.((((..,{{...(((.(((((((.(((((((((((,....}.})))))))))..((((.{..((((((...)))))),))))(((.......)))...(((((((((((.,.(.(((((((((....{{..,,)),,))}},...)))).).,.)))))))))))))))))).)))},}}...))))))))))..,,...(((((((({(,.(((((.....))))).}}.}}},........}))))))...

Transcripts

ID Sequence Length GC content
NM_001257133.2 NCBI
AGUGGCCUCGAGACCCUGCCUGCCUGAGGAGGCCUCGGUUGGAUGCGAA… 544 nt 0.5368
NM_001257134.2 NCBI
AGUGGCCUCGAGACCCUGCCUGCCUGAGGAGGCCUCGGUUGGAUGCGAA… 680 nt 0.5691
NM_032901.4 NCBI
AGUGGCCUCGAGACCCUGCCUGCCUGAGGAGGCCUCGGUUGGAUGCGAA… 484 nt 0.5248
Summary

This gene encodes a small single-pass transmembrane protein that localizes to mitochondria. This protein may play a role in coordinating the early steps of cytochrome c oxidase (COX; also known as complex IV) subunit assembly and, in particular, the synthesis and assembly of the COX I subunit of the holoenzyme. Mutations in this gene have been associated with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Forensic Context

A study in humans demonstrated that the COX14 gene was downregulated as part of the inhibited respiratory electron transport pathway in the prefrontal cortex, hippocampus, kidneys, and heart in sepsis [Pinheiro da Silva et al. DOI:10.1111/jcmm.17938].