Basic Information

Symbol
COX7A2
RNA class
mRNA
Alias
Cytochrome C Oxidase Subunit 7A2 COX7AL COXVIIa-L Cytochrome C Oxidase Subunit VIIa Polypeptide 2 (Liver) Cytochrome C Oxidase Subunit 7A2, Mitochondrial Cytochrome C Oxidase Subunit VIIa-Liver/Heart Cytochrome C Oxidase Subunit VIIa-L Cytochrome C Oxidase Subunit VIIaL Cytochrome C Oxidase Polypeptide 7A2, Mitochondrial Cytochrome C Oxidase Polypeptide VIIa-Liver/Heart Hepatic Cytochrome-C Oxidase Chain VIIa COXVIIAL COX7AL1 VIIAL
Location (GRCh38)
6:75237675-75250323
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001366293.2
Sequence length
462.0 nt
GC content
0.4675

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-146.00 kcal/mol
Thermodynamic ensemble
Free energy: -155.42 kcal/mol
Frequency: 0.0000
Diversity: 130.64
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((...(((...((((((......))))))(((..((((((((((((((((((((((((.....((((((((((((.....((.((((..(((((.............)))))..))).).))...))))).)))))))..........(((((((((((...((((((..(((((.(((.((((((...((((.((.((((..(((.((((((.....)))))))))...)))).((((((.............))))))..((((.((((.....)))).)))))).)))).)))))))))......((.((.(((((....))))).)).)).....)))))..)))))).....(((((..(((..(.(((....))).)..)))...))))))))))))))))........)))))))))...))))))))))).))))..))).)))...)))...
Thermodynamic Ensemble Prediction
(((...(((...{{{{{,.....,))}|}|(((..((((((((((((((((((((((((,((({,,{,((({{((,..{{{(({,(,({,,,,,,,}}.}.}}}}}}.,,)),..))),,{(((((((|..{{,{((({{....})))))|}))).)))))}....((((..(((((((.,.,.{..((((((((.(......).))))))))..}...,,,))))))).))))..((((((.............)))))).,{(((.,{.({{,....}).))}}))))),|||,,..{((((((({{({.((.(((((....))))).)).}}....((((((((.,{{{{,,,{{({.,..,,.}}},..})....)))).,,,,}))))))).,))))))))))).......}))))))))...)))))))))))},)))..)))}}))...)))...

Transcripts

ID Sequence Length GC content
NM_001366292.3 NCBI
AACACUGACUGACUUCUCUAUCUUUUCUUGUGCCUUGACAUCUGUCUUG… 889 nt 0.4286
NM_001366293.2 NCBI
GGUUCCGGCGUGGCCAUUUUCGUUGGUGGUGUUCAGUUGUGGCGGUUGC… 462 nt 0.4675
NM_001865.6 NCBI
AACACUGACUGACUUCUCUAUCUUUUCUUGUGCCUUGACAUCUGUCUUG… 910 nt 0.4582
Summary

Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]

Forensic Context

A study in humans identified the COX7A2 as one of the top ten most central mitochondrial genes via protein-protein interaction network analysis in sepsis patients [Li et al. DOI:10.1186/s12920-024-01891-x].