Basic Information
Symbol
COXFA4L2
RNA class
mRNA
Alias
Cytochrome C Oxidase Hypoxia Associated Subunit FA4L2
NUOMS
NDUFA4 Mitochondrial Complex Associated Like 2
MISTRH
NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 4-Like 2
NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 4-Like 2
NADH-Ubiquinone Oxidoreductase MLRQ Subunit Homolog
Cytochrome C Oxidase Subunit FA4 Like 2
Mitochondrial Stress Response Hypoxia
FLJ26118
NDUFA4L2
NADH:Ubiquinone Oxidoreductase MLRQ Subunit Homolog
COXFA4L2
Location (GRCh38)
12:57234903-57240715
Forensic tag(s)
Sudden unexpected death diagnosis
Other applications
MANE select
Transcript ID
NM_001394961.1
Sequence length
943.0 nt
GC content
0.6320
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-374.40 kcal/mol
Thermodynamic ensemble
Free energy:
-390.40 kcal/mol
Frequency:
0.0000
Diversity:
223.56
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((.(((............((((.((((...(((((((((((.((.......(((((((.....((((((.(((......))))))).))......))))))).((((.(((((((((...))))......(((((((........)))))))((((........))))..............((((....))))....))))).))))..............((((.((((.((((......)))).)))).))))(((((((((..(((..(.((.........(((((((((..((......))..)))).))))))))..)))..)))..))))))...........)).)))))))))))....)))).))))))).)))((((..((((((..........((((((...(((((((((((((.(((...............(((.(((((...))))).))))))))).........((((..(((.((((.((((((..(((((.(((.((((((....((((((((.(.....).))))...(((..(((((.((((........))))...).))))..)))((((((((((((.....)))))))))..)))............(((((((.....((((((...(((((((((......)))))))......(((((...))))).((((((((((((.(.((((((((((((((.((((...)))).))))))))).))))).).))))).)))).)))))...))))))..))))))).........)))).....))))))))).......)))))..))))))...)))).))).....))))..............)))))))))).....))))))......))))))..))))........((((((........))))))..
Thermodynamic Ensemble Prediction
.,,,.(((............((((.((((...(((((((((((.((.......(((((((.,,..((((({,(((,....,))))))).))...,,.))))))).{((,,((((({(((...}))}......(((((((........))))))),,.({.({(({((((,.,............,,((.{{.|,||....,)),).))}),.............,{{{,(((,{(((({{....,,,,.,,,)}))))||||||||,}}|||.}}}}.})...||..((((((((((,,{......,)),}))).))))),)),.)))}})})...,,,,,...........)).)))))))))))....)))).))))))),|}|((((..((((((.,..{({..{((,.,,...((((,((((((((.{{{,........,.....(((.(((((...))))).))},},||{..........})}..|||.,{{{.((((((,.(((((.(((.((((((....((((((((,,.....),})))...(({,{(({((.((((........))))...)}.))),.})}((((((((((((.....)))))))))..))}............(((((((.....((((((,..(({{(((((..,,,.}))))}}.))...(((((...))))).((((((((((((.(.((((((((((((((.((((...)))).))))))))))))))).).))))).)))).))),,.,.))))))..))))))).........)))).....))))))))).......)))))..))))})...))))})))})))))).....}}}..},|||,|,|||||||,....,)))}.,.....,))))))..))))),,.....((((((........))))))..
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| GUGUAUGUGUGAAAAUCAGGAAGAGCCAGCGGGGAGUGUGUGUUGCCAU… | 1240 nt | 0.6242 | |
| AGACUGGGAAAACAACGAUAUGGCAGGAGCCAGUCUUGGGGCCCGCUUC… | 943 nt | 0.6320 | |
| GUCUCCGCCUGCAGGUGCAGACAUCUGGAGGAGAGAGUCGGAGAGCAGA… | 1188 nt | 0.6279 |
Summary
Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Forensic Context
A study in mice demonstrated that the COXFA4L2 is a top marker gene for pericyte cluster 7 in the hippocampus [Bakulski et al. DOI:10.1093/toxsci/kfaa069]. In human sudden unexplained death (SUD) cases, whole transcriptome sequencing of heart tissue identified the COXFA4L2 as being significantly upregulated compared to heart-healthy controls, where it is involved in reducing mitochondrial activity and oxygen consumption [Neubauer et al. DOI:10.1007/S00414-025-03414-4].