Cartilage Acidic Protein 1
CEP-68
ASPIC1
FLJ10320
ASPIC
CEP68
Chondrocyte Expressed Protein 68 KDa CEP-68
Acidic Secreted Protein In Cartilage
68 KDa Chondrocyte-Expressed Protein
LOTUS
This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Forensic Context
A study in human blunt trauma patients demonstrated that the CRTAC1 was identified as one of 16 overlapping RNA transcripts in blood, selected by both LASSO and XGBoost machine learning models for the early prediction of multiple organ failure, though its specific mechanistic link to organ failure remains unknown [Duran et al. DOI:10.1186/s13613-024-01364-5].