Basic Information

Symbol
CRYM
RNA class
mRNA
Alias
Crystallin Mu DFNA40 1-Piperideine-2-Carboxylate/1-Pyrroline-2-Carboxylate Reductase Thiomorpholine-Carboxylate Dehydrogenase Ketimine Reductase Mu-Crystallin P2C/Pyr2C Reductase THBP NADP-Regulated Thyroid-Hormone Binding Protein NADP-Regulated Thyroid-Hormone-Binding Protein Mu-Crystallin Homolog Ketimine Reductase Crystallin, Mu Mu-Crystallin EC 1.5.1.25 EC 1.5.1.1
Location (GRCh38)
16:21238874-21303083
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001376256.1
Sequence length
1244.0 nt
GC content
0.5233

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-439.40 kcal/mol
Thermodynamic ensemble
Free energy: -461.84 kcal/mol
Frequency: 0.0000
Diversity: 346.03
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(.((...((((((((((((..((..((...((.((((.((((((..((((.((.(((((....)))))))..((((((((((....)))))))..)))..)))).)))))).)))).)).((((.(((....)))....))))..(((((((((.(((((((((((((((.((..(((((((.((((.((.(((((((.....((((.....))))..))))..))).)))))).)))).)))..)).)))).)))))((((...))))..)))))).)).))))))).)).))))))))))).)))...)))(((((((.((((((.((((((((.(((.((((((((((.(((((.((((((.(((((.(((.((((.((.(((((((...........)))))))..)).)))).))))).............(((((((((......))))).((.(((((((((((((((((((.(..(((((((((((((((.((.(((.....((((((((((...))))((((.((........)).)))).........(((((....)))))((((.(.((((........)))).)))))..(((((((((.(((.((((.((((((.....(((((((............(((((((......((((((((........))))))))...)))))))..)))))))....)))))).))))......))))))))))))))))))..))).)).))))))).......)).))))))).)))).))))).......))))).)))))))..))))))).)).)))).)))))))))......)))))).))).)))).)))).....((........))...(((((((.(((((((............)))))).....).)))))))....)))))).)).((((...(((....)))....))))...))))).........((((((((.....)))((((((((((((((((((.....((....(((...(((.((.....(((((...((((((((.((........)).)))).))))...))))))).)))....)))......)).....))))))....(((((.........))))).((((.(((((.((.......))..))))).)))).....))))))))))))))))).((((((...))))))..(((((.......))))).
Thermodynamic Ensemble Prediction
,.((,(.((((((((((((..((.{((.{{((.((((.((((((..((({.{{.((((,....}))))||..((((((((((....)))))))..)))..)))}.)))))).)))).},.{{{,.{{{,.,,)))..,,}}}|,.(((((((((.(((((((((((((((.((..(((((((.((((.((.(((((((.....((((.....))))..))))}.,)).)))))).)))).)))..)).)))).)))))((({...})))..)))))).)).))))))))),.,,))))))))).)))...})}|||{(({.{{{{{({{,,{({,{{{|{{(((((.,({,.,}|||}|||.|{|||{{{|(({..,{{.{,.,{(({{{.........,{||||||}{({.(((((((({||{{{,,..{,{|,,(((((((((((((((..((..((.,((({{{{{((((((((((.(..(((((((((((((((.{(.(((.....((((((((((...))))((((.((........)).)))).........{((({....))))|((((.{.((((........)))).,)))),.(((((((({,(((.(((({((((,{{,,,.{{{{|||.,.,}}}}}}}.(((((((......((((((((........))))))))...)))))))|{||,||,|,...}))})),)))),,,...))))))))))))))))))..))).)).))))))).......)).))))))).))))}}))))}.,{{,,.{|||{|,}}||||.{{{,...))).))).}))))))),.))..))))))),.))))))))..,,......((,..,,...}),.,||{{,((,.{{{.,{}},.}}.}}},.}.,}))))...))))))))).})}}))}}}}))}}}|....|||}},|}}}||,}}))),,,|,||,.,,,,....{{{(({{{.....)}}((((((((((((,(((((,..,.(({{{{(((,..{{{,{,....,(((({.,{{{(((({{.{{.|,,..,,)}.)))),}}}}...}}|||,,,|,|,...,||..,,,,|},|,,.}})})),,,,,,|,,,,,..,},.})))}.||||.{{|||,,{..,,,,.,}..}}}}).})}}.....))))))))))))}}})}.||||||,..)),,,,..(((((.......))))).

Transcripts

ID Sequence Length GC content
NM_001376256.1 NCBI
GCGGUGCGGAGACUGAGGUUAGAAGGCACAGGUGGCGAGAUGAGCCGGG… 1244 nt 0.5233
NM_001888.5 NCBI
GCACAAGCUUUCUUGUCUGCCACUAUGUGAGAUAUACCUUUCACCUUCU… 1482 nt 0.5189
Summary

Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. [provided by RefSeq, Sep 2014]

Forensic Context

A study in humans identified the CRYM as a gene expression marker that is up-regulated in heart tissue from patients with various structural heart diseases compared to controls, with a mean fold change of 1.7969 and an adjusted p-value of 1.1463 × 10^-24, and it was part of a 62-gene signature that achieved approximately 95% classification accuracy using a random forest model [Fajarda et al. DOI:10.1186/s13040-020-00217-8]. In a separate human study of post-mortem tissues, the CRYM was found to be down-regulated in the hippocampus and kidney as part of the metabolism of amino acids and derivatives pathway in patients who died from septic shock [Pinheiro da Silva et al. DOI:10.1111/jcmm.17938].