Basic Information

Symbol
CSNK2B
RNA class
mRNA
Alias
Casein Kinase 2 Beta Ckb1 Ckb2 Casein Kinase 2, Beta Polypeptide Casein Kinase II Subunit Beta Protein G5a CK II Beta Phosvitin CK2N G5A Alternative Name: G5a, Phosvitin Casein Kinase II Beta Subunit CSNK2B-LY6G5B-1072 CSNK2B-LY6G5B-1103 CSNK2B-LY6G5B-532 CSNK2B-LY6G5B-560 CSNK2B-LY6G5B-562 POBINDS CSK2B CK2B
Location (GRCh38)
6:31665227-31670343
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001320.7
Sequence length
929.0 nt
GC content
0.5318

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-294.00 kcal/mol
Thermodynamic ensemble
Free energy: -308.03 kcal/mol
Frequency: 0.0000
Diversity: 150.93
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((...((((.((((.(((((((((.((((((((..(((..((((((((((......))))..)))).))..))).((((((....))))))....(((((.(((((((.((.((((.((.(((.(((.((.....).).))).)))..)).).)).).)).)))....))))....)))))..))))))))............)))))))))..(((((((.....(((((((.......(((((((((.(((...((((..(((..........)))..)))).......((((((((((((((((((((.....(((((((..........(((.(((......))).)))....(((((...(((.(((((.((((....))))....................((((((((.(((((..((((((.(((((((((..((.(((((((....)))....)))).))..)))))..........(((((((.....))))))).)))).))))))...))))).)))))))))))))))).)))))....((((((....))))))........(((.....))).(((((.....))))).(((......)))..((((....(((....(((......(((((.......))))))))....)))....)))).))))))).....))))))))).)).))))))))).......(((....)))(((((.(((...))).).))))........))).))))).)))).((.((...)).))...........))))))).)))))))(((...((((((..(((..((.(((....((((...))))...))).....))..)))..)))))))))......)))).))))....)))))...................
Thermodynamic Ensemble Prediction
.(((((...((((.((((.(((((((((.((((((((..(((..{(((((((((......))))..))))),)..))).((((((....))))))....(((((.(((((((.((.((((.((,(((.(((.{(.....,.).))).)))..}},),)).).)).)))....))))....)))))..))))))))..{{.....}}.)))))))))..(((((((.....(((((((.......(((((((((.(((...((((..(((..........)))..)))).......((((((((((((((((((((.....(((((((..,.......{((.(((......}}}.}}}.{{,(((((...(({.(({{{.{(((....}))}.....,....,,,.......((((((((.(((((..((((((.((({(((((,.((.((((,({....}}}..,.)))).)),.))))),{....,,..(((((((.....))))))).)))).})))))...))))).)))))))))})))}}}.}}))}....{{|{{({{.,||},,,.,,.,,..(((.....))).(((((.....))))).(((......)))..}||}}...,,,.,|,|{||||,,|(((((.......)))))||{..|||}}..,|},}..))))))).....))))))))).)))}})))))))..,....(((....)))(((((.(((...))).),})))........))).))))).)))).{{.{,...}}.,,...........))))))).)))))))(((...((((((..(((..((.{,({...((((...))))...)),.....))..)))..)))))))}},,....)))).))))....)))))...................

Transcripts

ID Sequence Length GC content
NM_001282385.2 NCBI
AAUUUCCACUCCCCCCACCCCACUUCGCCUGCCGCGGUCGGGUCCGCGG… 920 nt 0.5315
NM_001320.7 NCBI
AAUUUCCACUCCCCCCACCCCACUUCGCCUGCCGCGGUCGGGUCCGCGG… 929 nt 0.5318
Summary

This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulated the CSNK2B in microglia, which is a component of the mitophagy pathway [Oladapo et al. DOI:10.3390/Ijms26020649].