Basic Information

Symbol
CST6
RNA class
mRNA
Alias
Cystatin E/M Cystatin-M Cystatin-E Cysteine Proteinase Inhibitor Cystatin M/E Cystatin 6 Cystatin-6 ECTD15
Location (GRCh38)
11:66012008-66013505
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001323.4
Sequence length
592.0 nt
GC content
0.6385

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-244.60 kcal/mol
Thermodynamic ensemble
Free energy: -254.08 kcal/mol
Frequency: 0.0000
Diversity: 203.52
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
......(((((.(((..((((((((((.(((.(((((..(((((...((.......))...)))))((((((((.....(((((....((((....)))).......)))))..))))))))))))))))..)).)...)))))))..))).))).)).((((((.....(((....)))......))))))(((((((((..((((((...........(((((..((..................(((...((((((.....(((.....))).(((((...))))).........((((.......))))...((((((..(((((((((.....((((.....)))).(((((((..(((((((.(((.....(((((....)))))(((((((.......))))))).)))....)))))))..)))))))...))))))......)))..))))))...(((((....))))).))))))....)))(((((.(((....))).)))))....((.(((((((((((....)))))...)))))).))))..)))))........))))))..))))))...))).
Thermodynamic Ensemble Prediction
...(((((.((((((((((((.,({,,.,,..{|((((((((,(...((,,{{,{,,({((|{|({({((((((((((((((((.,{((((,.(((||{(.{{,,..(((((((((((({((((((((....,,})..)))))).)...)))))).,.})))))....}}...}}}})),))})},.))))),)))),))))},}}))}||,......,})}}.{{....))...........,.{,{{{...({((((.....(((.....))),|{{|{,,,}}}||,{{..,,..{(((,......}}}}..|((((({..{{{((((({...,.((((.,...}}||.(((((((..(((((((.{{{.,{{{(((((....)))))|{(((((.......))))))}.)))....)))))))..))))))).,,}))))).....,)))..)))))}...(((((....))))).))))))....))){{{||,(((....))).})))),})))})))))))),}.)))).))))))).))))){(({((...{{,........}))))).,|||,{{.....)),

Transcripts

ID Sequence Length GC content
NM_001323.4 NCBI
ACUCACGGCUCUGAGGGCUCCGACGGCACUGACGGCCAUGGCGCGUUCG… 592 nt 0.6385
Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the CST6 showed strong signals in skin but exhibited high cross-reactivity in other mucosal tissues and fluids, leading to its exclusion from the final multiplex assay for body fluid identification [Xu et al. DOI:10.1371/journal.pone.0100123].