| ID | Sequence | Length | GC content |
|---|---|---|---|
| ACUGCGCGCCGCCUCCGAGGCGGCCUAGGUGCGGUGGGCGCUCGUCCCC… | 2039 nt | 0.4949 | |
| AUUGGGACUCCGCGAGAGGGCCUAGGAUUGGAGGGCCCAGGCAGAGCCC… | 2251 nt | 0.5078 | |
| AUCACGCACUUCAGGCUGCGAUAACGAGGUGGAGUGUAGAAUCCGACGA… | 2137 nt | 0.4871 | |
| AGGUCGCGCGCCCCUUCCGGCGCGGGGAGGGCGCUGAAGAUCGGGGCCG… | 2091 nt | 0.5041 |
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]
A study in human post-mortem blood samples demonstrated that the ADIPOR1 shows an up-regulated expression pattern after death and is involved in the positive regulation of insulin receptor signaling pathway, with its expression data used for post-mortem interval (PMI) estimation [Antiga et al. DOI:10.1038/s41598-021-96095-z]. A separate scoping review of human twin studies reported that muscle mRNA expression of the ADIPOR1 was correlated with birth weight in elderly twins [Dany Laure Wadji et al. DOI:10.1371/journal.pone.0315549].