Basic Information

Symbol
CXCL10
RNA class
mRNA
Alias
C-X-C Motif Chemokine Ligand 10 IP-10 GIP-10 SCYB10 IFI10 Crg-2 Mob-1 INP10 C7 Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 10 10 KDa Interferon Gamma-Induced Protein Small-Inducible Cytokine B10 C-X-C Motif Chemokine 10 Protein 10 From Interferon (Gamma)-Induced Cell Line Interferon-Inducible Cytokine IP-10 Chemokine (C-X-C Motif) Ligand 10 Gamma IP10 Gamma-IP10
Location (GRCh38)
4:76021118-76023497
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Wound age identification Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001565.4
Sequence length
1175.0 nt
GC content
0.3745

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-284.20 kcal/mol
Thermodynamic ensemble
Free energy: -306.04 kcal/mol
Frequency: 0.0000
Diversity: 253.24
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((.((((((....(((((((.....)))))))........))))))......)))))((((.((.((((.........))))))...))))((((((((((((.((((((.((((...((((.((((((((((..((((((((((...((((.........))))..)))).....((((.........)))).)))))).....((((((((((((..(((.....(((((((..((((((.(((.((((((...))))))....((((((((((..(((((((.((((..(((..(((((.(((((.(((((((((((((((((.......(((((..(((((...))))))))))..........(((((((............))))))).(((((((...(((.(((((...)))))......((((.((((((.((((((...((..(((..(((((((.........)))))))........((((((((....))))))))......)))))...)))))))))))).))))...)))...)))))))..))).))))))))...........(((((((.....(((.....)))...))))))).)))))).)))).).))).))..))).)))).))))))).))))))))))......(((.((....))..)))((((.((((.((((((((((...((....))..))))))))))....(((((((((............)))))))))((((....))))(((.((..(((((((.((((((..(((....))))))......(((((((((((....))))............(((((((((...(((((....))))).....)))))))))(((((....)))))..)))))))........))).)))))))..)).)))....((((((.....(((((((.(((((((((...................))))))).)).)))).)))))))))............)))).)))).....))).))))))...))))))).....))).)))))).)))))).........))))))))))..))))..)))).)))..............))))))))))...))))).....................
Thermodynamic Ensemble Prediction
(((((.((((((....(((((((.....)))))))....,...))))))......)))))((((.,..{((({,.......,}},)),,}))))((((((((((((.,{({,,.||||,..((((.((((((((((..((((((((((...((((.........))))..)))).....((((.........)))).)))))).....((((((((((((..(((.....(((((((..((((((.(((.((((((...))))))....((((((((((..(((((((.((((..(((..(((,(,((((,.,(((,,(((((((((((.,,,...(((({.,(((((...))))))))))...,,.....(((((((............))))))).(((((((...,,,.(((((...)))))......,(((.((((((.((((((...(,..{((..{((((((.........))))))}........((((((((....))))))))......)))))...)))))))))))),))}}...})}...}))))))..))).))))))))....}}}....||||{||.....,,,,,,{{{|{{{{||,,,,..,,))))}))))},,))},))..))).)))).))))))).)))))))))).....,{({.{(,...}}..}}}{{{{,({((,((((((((((.,.{(....},..)))))))}}}....{{{{{((((.,........,.}))}}}}}|(((({{,,||||{{,.,,,{(({{,,{.{{{{{{.,(({....}))))}......{{{{{{||{||....}}}}............(((((((((...(((((....))))).....))))))))),||||,,},),,,,..}))}))}||.,.|..}))})))))))|,}|||||..,,{((({{{{{{((,,,,||}}|||{{{||,,,..}}},},.....,},}||||||||.,}}}}|}},}}}}},..,,,.....,,)}}),,))),,,,.))).))))))...))))))).....))).))))))))))))).........)))))))))},.)))){{||||.|||.......))).}}}))))))))))...))))).....................

Transcripts

ID Sequence Length GC content
NM_001565.4 NCBI
GAGACAUUCCUCAAUUGCUUAGACAUAUUCUGAGCCUACAGCAGAGGAA… 1175 nt 0.3745
Summary

This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020] CIViC Summary for CXCL10 Gene

Forensic Context

A study in mice demonstrated that myocardial infarction (MI) activates the cGAS-STING-IRF3 pathway in cardiac macrophages, leading to robust type I interferon (IFN) production and interferon-stimulated gene (ISG) expression, including the CXCL10 [King et al. DOI:10.1038/nm.4428]. In a rat model of cavernous nerve injury erectile dysfunction (CNI-ED), whole-transcriptome analysis identified the CXCL10 as a core hub gene with upregulated expression, and it was suggested to be regulated within a competing endogenous RNA network involving specific miRNAs [Huang et al. DOI:10.1080/21655979.2021.1973863]. A study in mice demonstrated that the CXCL10 was significantly upregulated (310.472-fold) in skeletal muscle at 12 hours following an incised injury, as identified through DNA microarray analysis [Gaballah et al. DOI:10.1016/j.forsciint.2016.06.027]. This finding was part of a broader transcriptomic investigation that identified numerous differentially expressed genes, with the temporal expression patterns of selected cytokines suggesting their potential utility for forensic wound age estimation.