Basic Information

Symbol
CXCL13
RNA class
mRNA
Alias
C-X-C Motif Chemokine Ligand 13 BCA-1 BLC ANGIE2 SCYB13 BLR1L ANGIE Small Inducible Cytokine B Subfamily (Cys-X-Cys Motif), Member 13 (B-Cell Chemoattractant) B Cell-Attracting Chemokine 1 B Lymphocyte Chemoattractant Small-Inducible Cytokine B13 C-X-C Motif Chemokine 13 B-Cell Chemoattractant CXC Chemokine BLC BCA1 B-Cell-Homing Chemokine (Ligand For Burkitt'S Lymphoma Receptor-1) Chemokine (C-X-C Motif) Ligand 13 (B-Cell Chemoattractant) Chemokine (C-X-C Motif) Ligand 13 B-Cell-Attracting Chemokine 1 B-Lymphocyte Chemoattractant Angie
Location (GRCh38)
4:77511753-77611834
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001371558.1
Sequence length
1171.0 nt
GC content
0.3826

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-281.80 kcal/mol
Thermodynamic ensemble
Free energy: -305.06 kcal/mol
Frequency: 0.0000
Diversity: 294.79
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((((((...((((.(((....))).))))...)))))......(((.((((.(((.(((((.(((((.(((((.(((((((.....))))...(((((((..((...))..)))))))...........))).))))).))))).)))))..))))))))))((((........))))...(((((((..(((((.....((((((((.((.(((.....(((...(((((((......(((..((((((((..((((.(((.(((((((((...((((..((((((((((((((...((((..(((.((..(((((((.......))).))))..)).)))))))..)))))..(((((((..((((((((((.............((((((....((((..((((....((((.......))))..((((((((((((((......((((((......))))))...............)))))))))))))).((((........))))(((((((..((((.....)))))))))))..........................))))..))))))))))..)))))))))).....))))))).........)))))))))....(((((.(((((...))))))))))...((((((.(((((((((.....((((((..................((((((((((.((..........)).))))))))))...)))))).....)))))....)))))))))).(((((((((............((((((...))))))(((((.(((..((((......))))..)))..)))))..(((((((.(((((((...............))))))).....((((...)))).((((((...))))))....)))))))((((..((((.............))))...))))))))))))).....))))...)))...(((((((((((....))).)))))))))))))).))).)))).....)))))))))))....)))))))....)))....))).)).))))))))(((((((...)))))))....))))).))))))).....................(((((...)))))))...............
Thermodynamic Ensemble Prediction
...,.(((((...((((.(((....))).))))...)))))...{{{((.{((((.(((.(((((.(((((.(((((.(((((((.....))))...{((((((..({...})..))))))}...........))).))))).))))).)))))..))))))))|,((((........)))),..(((((((..((({{.....((((((((.((.(((.,,..(((...(((((((......{(,.{((((((((..((((.(((.(((((({((,..((((..(((((({((({{,{...((((..(((,((,.{{(((,,.,,,,..}))}}}}},,)}.}}}|}))||,|||||.((((({{..((((((((((..{,....,,...{(((((....((((..((((....{{,{.,,,,.,|},...((((((((((((((......((((({....,,}}}}))..,............)))))))))))))).((({........}))){((((((..((((.....))))))))))}.....,,.,}},..............))))..)))))))))).,)))))))))).....))))))}.....,,.||}}))}}}},,{{(((((.{((({...}))))}})}}.,}|||||{.{{{{{{{{{,,...{{{{{|,,..,,},.,,,,,},,,((((((((((.((..........}).))))))))))...}}},,,.,,..,,,..,,,,}}}|}}}|||,(((({(((,.,.,,,......((((((...))))))(((((.(((..((((......))))..))}..))))),,(({(({,.{{{{|||,,.............}}))))}........},)},)|,.((((({...)))))).......,,,}{|||..{{,,.....,,,}}..,})}}...})}))))}}})}}...,.))))...})}...{(((((({(((....))).)))))))})))))).))).)))).....)))))))))}}....))))))),...)))....))).)).))))))))(((((((...)))))))....}}})).))))))}..........,,....},..,|||,|.,,}})))},...,,,},.......

Transcripts

ID Sequence Length GC content
NM_001371558.1 NCBI
ACAGCCUGGACUCAGAGCUCAAGUCUGAACUCUACCUCCAGACAGAAUG… 1171 nt 0.3826
NM_006419.3 NCBI
GAGAAGAUGUUUGAAAAAACUGACUCUGCUAAUGAGCCUGGACUCAGAG… 1203 nt 0.3815
Summary

B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

Forensic Context

A study in mice demonstrated that the CXCL13 was significantly upregulated in microglia at 14 days post-controlled cortical impact, indicating its role in chemokine signaling during the subacute neuroinflammatory phase following traumatic brain injury [Izzy et al. DOI:10.3389/fncel.2019.00307].