This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]
Forensic Context
A study in mice demonstrated that the CXCL5 was the most upregulated gene throughout the post-injury period in incised skeletal muscle wounds, showing high expression from 6 through 36 hours with a significant decrease at 48 hours, and its distinct temporal expression pattern, along with other cytokines, suggests potential for forensic wound age estimation [Gaballah et al. DOI:10.1016/j.forsciint.2016.06.027].