The protein encoded by this gene is a member CXC chemokine family. The encoded protein is a chemotactic for neutrophil granulocytes and has antibacterial action against gram-negative and gram-positive bacteria. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Jun 2020]
Forensic Context
A study in human skin demonstrated that the CXCL6 is significantly up-regulated in thermally injured tissue compared to normal skin, as part of a comprehensive temporal gene expression profile of wound healing [Greco et al. DOI:10.1016/j.burns.2009.06.211].