Basic Information

Symbol
DCD
RNA class
mRNA
Alias
Dermcidin AIDD DSEP Preproteolysin DCD-1 HCAP PIF Diffusible Survival/Evasion Peptide Proteolysis Inducing Factor Survival Promoting Peptide EC 3.4.-.-
Location (GRCh38)
12:54644589-54648493
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_053283.4
Sequence length
519.0 nt
GC content
0.4798

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-147.40 kcal/mol
Thermodynamic ensemble
Free energy: -156.76 kcal/mol
Frequency: 0.0000
Diversity: 105.12
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....(((((.(((..((.(((((..(((....((((.....))))))).((........))...(((((...((.((((..((((((......((((((...(((((((((((..((((......((((((...))))))((((......))))...((((.....(..((....))..)....)))).......))))..))).)))))))).))))))..(((......))).))))))..)))))).)))))(((((........)))))((.(((.......))).)).))))))).)))...)))))...((((((.(((((..(((((.......)))))...(((....)))..((((((...)))))).)))))(((((...((((((((........((((.....((.....))....))))(((((..........)))))....................................))))))))...)))))..))))))......
Thermodynamic Ensemble Prediction
.....(((((.(((,.((.(((((..(({..,(((({.....)))})}}.{{.....,..}|,{(({,,|},}|,.((((..((((((....,.((((((...(((((((((((..((((......((((((...))))))((((......))))...{{{(,,..,{,.{{....||,,}||..,}))....,,,))))..)))})})))))).))))))..(((......))).))))))..))))}},|||||{{{{{........}}}},{|,(((.......))).)).))))))).))}...)))))...((((((.((({{.,(((({.......}}}}}...{{{....}))..((((((...)))))).))))){((((...((((((((.,{{....(((({,,..((,....},....},,),||{|},,..},,.})))}}....}}}.......................,}}...))))))))...))))}..))))))......

Transcripts

ID Sequence Length GC content
NM_001300854.2 NCBI
GACACCCUAGAUCCCAAGAUCUCCAAGGAUUUGGUGGCAUACCCACUCC… 583 nt 0.4854
NM_053283.4 NCBI
GACACCCUAGAUCCCAAGAUCUCCAAGGAUUUGGUGGCAUACCCACUCC… 519 nt 0.4798
Summary

This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Forensic Context

A study in humans demonstrated that the DCD is a specific and excellent marker for sweat identification, as its mRNA and protein were not detected in other body fluids like saliva, semen, vaginal secretions, urine, or blood [Sakurada et al. DOI:10.1016/J.Forsciint.2009.10.015].