Basic Information

Symbol
DEFB130A
RNA class
mRNA
Alias
Defensin Beta 130A DEFB-30 DEFB30 DEFB130 Defensin, Beta 130 Beta-Defensin 130A Defensin Beta 130 Beta-Defensin 130 Beta-Defensin 30 Defensin, Beta 30 DEFB130L
Location (GRCh38)
8:12310962-12318316
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl UniProt GTEx

MANE select

Transcript ID
NM_001037804.1
Sequence length
240.0 nt
GC content
0.4042

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-45.90 kcal/mol
Thermodynamic ensemble
Free energy: -49.95 kcal/mol
Frequency: 0.0014
Diversity: 48.10
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.......((((((.((((.(((((((......(((((((.......((((((............((((.......))))............)))))).....)))))))...))))))).......(((((((((.((.(((.((((...))))))).)).))...........))))))).)))).)))))).....(((((............)))))...(((((.....)))))..
Thermodynamic Ensemble Prediction
.......((((((.((((.(((((((.{.{{,((({(((,.,....,,{{{{,....{{{,.,,({{{.},,.,,))}}........,.,,}},}}),,,,,},))))).}.))))))).......(((((((((.((.((,{((((...))))))).)).))...........))))))).)))).)))))).....(((((............)))))...(((((.....)))))..

Transcripts

ID Sequence Length GC content
NM_001037804.1 NCBI
AUGAAACUCCAUUCCCUUAUUUCUGUUCUCCUCCUCUUUGUGACUUUAA… 240 nt 0.4042
Summary

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014]

Forensic Context

A study in mice demonstrated that the DEFB130A transcript, an antimicrobial peptide, increased in abundance within one hour postmortem, exhibiting a profile with two distinct maxima over the experimental time course [Pozhitkov et al. DOI:10.1098/rsob.160267].