Basic Information

Symbol
DEFB4A
RNA class
mRNA
Alias
Defensin Beta 4A HBD-2 SAP1 Defensin, Beta 2 DEFB102 DEFB-2 DEFB2 DEFB4 Skin-Antimicrobial Peptide 1 Defensin, Beta 4 Beta Defensin-2 Beta-Defensin 2 BD-2 Defensin, Beta 4A Beta-Defensin 4A Beta Defensin 2
Location (GRCh38)
8:7894677-7896716
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004942.4
Sequence length
337.0 nt
GC content
0.4837

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-95.80 kcal/mol
Thermodynamic ensemble
Free energy: -103.44 kcal/mol
Frequency: 0.0000
Diversity: 52.45
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(.((..((((((((((((((((.((.((((((((((.((.(((((..(((((((.....(((((.............(((((((.....)))))))...(((((((((((....)))).)))).))).....((.((((((((((((((....((.((.((((......)))).))))....)))))..))))).))))))))))).....(((......)))...))))))).)))))..))..)))))))))))))).........)))))...))))))).))..)).)......................(((((((....))))).)).
Thermodynamic Ensemble Prediction
.......,{((((((((((((((((.(,{((((((((({,({.(((((..(((((((.....(((((............,{{{((((.....)))))}|,..(((((((((((....)))),,))).)))..,,.((.((((((((({(({{.,,,((.{{.((((......)))).,}),...,)))})..))))).)))))))))))...,,(((......))).,,))))))).)))))..))..,))))))))))))).........)))))...))))))),)|,{{(.,.},||,...,,...........||||{{{....)}))),},.

Transcripts

ID Sequence Length GC content
NM_004942.4 NCBI
AGACUCAGCUCCUGGUGAAGCUCCCAGCCAUCAGCCAUGAGGGUCUUGU… 337 nt 0.4837
Summary

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human skin demonstrated that the DEFB4A (DEFB4), an inflammatory/immune response gene, was significantly up-regulated in thermally injured tissue compared to normal non-wounded skin during the early wound repair process [Greco et al. DOI:10.1016/j.burns.2009.06.211].