Basic Information

Symbol
DMD
RNA class
mRNA
Alias
Dystrophin DXS142 DXS164 DXS206 DXS230 DXS239 DXS268 DXS269 DXS270 DXS272 BMD MRX85 Dystrophin (Muscular Dystrophy, Duchenne And Becker Types), Includes DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272 Muscular Dystrophy, Duchenne And Becker Types Mental Retardation, X-Linked 85 Mutant Dystrophin CMD3B
Location (GRCh38)
X:31097677-33339609
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004006.3
Sequence length
13992.0 nt
GC content
0.4225

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
- kcal/mol
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
-

Transcripts

ID Sequence Length GC content
NM_000109.4 NCBI
GGCAGUAAUAGAAUGCUUUCAGGAAGAUGACAGAAUCAGGAGAAAGAUG… 13854 nt 0.4232
NM_004006.3 NCBI
AUCAGUUACUGUGUUGACUCACUCAGUGUUGGGAUCACUCACUUUCCCC… 13992 nt 0.4225
NM_004009.3 NCBI
AUGCUGUCUGUGAAGCUGAAUCUGUGAGAACACCUCACUAUUCACGGCA… 14000 nt 0.4241
NM_004010.3 NCBI
UGCUGUCUGUGAAGCUGAAUCUGUGAGAACACCUCACUAUUCACGGCAA… 14083 nt 0.4240
NM_004011.4 NCBI
CUGAGAAAGACAGAUUGCAAUGACUGAGAUGAUUUUGCUAAUUUUUUUU… 9751 nt 0.4217
NM_004012.4 NCBI
CUGAGAAAGACAGAUUGCAAUGACUGAGAUGAUUUUGCUAAUUUUUUUU… 9894 nt 0.4208
NM_004013.3 NCBI
ACACUAGCAAUGGCAAAGCUUUGUGCGGAGGCAUUGCUGGCUGCUCUGA… 7416 nt 0.4239
NM_004014.3 NCBI
GUUUUCUCAGGAUUGCUAUGCAACAGGAUCAGUGCUGUAGUGCCCGGUU… 5627 nt 0.4175
NM_004015.3 NCBI
GCAGUGCUUUCAGCUGUGAGCUUGGGCGGCGGCGGCGGCGGCGCUCCAC… 4676 nt 0.4065
NM_004016.3 NCBI
GCAGUGCUUUCAGCUGUGAGCUUGGGCGGCGGCGGCGGCGGCGCUCCAC… 4644 nt 0.4061
Showing 1 to 10 of 17 entries
Summary

This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. [provided by RefSeq, Dec 2016]

Forensic Context

No relevant information is available at the moment.