This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008] CIViC Summary for DRD5 Gene
Forensic Context
A study in mice demonstrated that the DRD5 (Drd5) is a protein-coding gene with low expression across the nucleus accumbens, prefrontal cortex, and ventral midbrain in experimentally naïve animals selectively bred for high or low methamphetamine consumption [Hitzemann et al. DOI:10.3390/brainsci9070155].