Basic Information

Symbol
DYNLL1
RNA class
mRNA
Alias
Dynein Light Chain LC8-Type 1 DLC1 DLC8 PIN Hdlc1 DNCL1 LC8 Protein Inhibitor Of Neuronal Nitric Oxide Synthase Dynein, Cytoplasmic, Light Polypeptide 1 Dynein Light Chain 1, Cytoplasmic 8 KDa Dynein Light Chain DNCLC1 Cytoplasmic Dynein Light Polypeptide HDLC1 LC8a
Location (GRCh38)
12:120469804-120498495
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003746.3
Sequence length
663.0 nt
GC content
0.4630

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-170.00 kcal/mol
Thermodynamic ensemble
Free energy: -185.09 kcal/mol
Frequency: 0.0000
Diversity: 216.53
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((.(((.((((.((.....(....(((((((((((...(((((((..((((......((((....)))).(((.......)))...........((((((.(...((.((((((.((((...((((((........))))).)...))))......))).)))))...).)))))).))))..)))))))))))))))..)))......).....)).)))).))).))).....((((((((((((..(((((..((((.((....)).))))((.((((((.((((.........(((.((((((.(((((...(((((.................(((((....(((((((.(((..((((..............)))).))).)).)))))...))))).......(((........)))..(((((........((((((...(((((((((...)))))((((....))))....))))..)))))).......))))).....((((((((....))))))))..)))))))))))))))).)))...(((.(((((((..(((....))).))))))))))........)))).)))))).)).))))).)))).....)))))))).........(((((...)))))...
Thermodynamic Ensemble Prediction
..,{(,{{{,{{(({({,{{,{{.{{{{{,((((((((...(((((((.,(,((..(((,{(((.({..(((.((((((((.(({{,,..,,,,...,{{((((,......}))).}}((({...|(((({........})))).}...))))..},,,)))))).)).))))).))))))))),,))))))))))))))}{({((((({.{(.,,,(({(({(|.(({{{{.....{((((,,,,{{({...(((((.(..((((((..,{{...)),..)))))},,|.}}}}}(((.,(({(((,,.,|||||.,,|.,.,...,},....},}}}.,{{{((,,..(((((((.{{{..{(((,,....,,,,....}}}}.))).)).)))))...))))),}.....{((........))).,|||||,....,{,{,,,,|.,,{{{.(((({...})))){{{|....}))),...}},)}})))))},,.}}.})))))))),.((((((((....))))))))..,,,,}))))}))))),|}}}...,,||{((((({..{{{....}}}.,}}},,,}}},,,..,,,,|||||,||.}|||||||,,.,..........,........,,,,,,{{{||..,))))},},

Transcripts

ID Sequence Length GC content
NM_001037494.2 NCBI
CUUCGGGCGCUGACAGGGAGAGCCUGGGGCCGGGCCGUGUGGAUGCCAU… 822 nt 0.5195
NM_001037495.2 NCBI
AGAUGCGCCACGGUUUCGGUAGCGACGGUAUCUCUAGCCGGGCCUGAGC… 677 nt 0.4668
NM_003746.3 NCBI
AGAUGCGCCACGGUUUCGGUAGCGACGGUAUCUCUAGCCGGGCCUGAGC… 663 nt 0.4630
Summary

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the DYNLL1 was notably upregulated in excitatory neurons in post-mortem brain tissues stored for 24 to 54 hours, where it is involved in neuronal projection development and synaptic vesicle endocytosis and physically interacts with neuronal nitric oxide synthase [Guo et al. DOI:10.1016/j.ijbiomac.2025.147708]. A study in mice demonstrated that the DYNLL1 is a marker for electrophysiologically associated cardiomyocytes, as it is highly expressed in the ventricular cardiomyocyte cluster vCM5 following myocardial infarction [Bian et al. DOI:10.3892/mmr.2025.13680].