Basic Information

Symbol
DYNLT1
RNA class
mRNA
Alias
Dynein Light Chain Tctex-Type 1 TCTEX1 Tctex-1 TCTEL1 T-Complex-Associated-Testis-Expressed 1-Like 1 T-Complex Testis-Specific Protein 1 Homolog Protein CW-1 TCTEX-1 CW-1
Location (GRCh38)
6:158636474-158644755
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006519.4
Sequence length
730.0 nt
GC content
0.4342

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-185.60 kcal/mol
Thermodynamic ensemble
Free energy: -201.44 kcal/mol
Frequency: 0.0000
Diversity: 209.35
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((((((..((((((......))((.((..(((.(((.(((((..((((...((((((((.(((...(((((((.((...)).)))))))..)))...((((((((((...((((..(((((((....(((((((.(((((.....(((..((...))..)))...))).)).))........)))))....)))))))))(((.....))).............((...(((((((((..((...........))..)))))))))...)).(((((.......)))))((((((.......))))))((((((.((((((..((.(((......))).)).))))))))))))....(((((((...........))))))).)))))))))))))))))))).)))).)))))..))))))..)).)).((((((((...((.(((...........))).))....))))))))..(((((((..(((((((......))........(((((.(((.(((((......((.(((.((((((((.....(((((((........))))))).....))))))))..))).)).....))))).)))..)))))............)))))...)))))))....)))).))))))))............................................(((((...))))).........
Thermodynamic Ensemble Prediction
..((((((((..((((,({.{(((({((((,.{((({((,.({(,{,{(((({({(({(((((,(((...(((((((.((...}).)))))))..))}..,((((((((((...{{((..(((((((,...(((((({.{((({.....(((..((...))..)))...))).)).}}........)))))..,,,)))))))){((.....))}..,...{((({.,....,,}})}}.,,,,.((({((...(((((({.........,}}}.,||))}..)))))),}.|((((((.......))))))((((((.((((((,.{(.(({......))).)).))))))))))))....(((((((,..........))))))).,,)))))))))))}}}}},,.)))),}}|||,.||||||,.,,....((((({{(,.{((,({............|||,|{,||.,||||||}....|}}}},.,}))))))..........,|{,{,{{{,|.{{{{{..,{({(......||}|,,{,|||,}}..,||,|||},.}})}}))))),)}...,,,}}))))}..)))}|........{{||||..|||,,....}))}}}}}),.,,..)))))...}},.)))).))))))))...,,.............,,...........,,.......},,}|,|||,,.}))},.,,,.....

Transcripts

ID Sequence Length GC content
NM_001291602.2 NCBI
ACUCAGGGAGCCGGAGGGGACGCGCCGGAGGAAAGAUGGAAGACUACCA… 688 nt 0.4390
NM_001291603.2 NCBI
ACUCAGGGAGCCGGAGGGGACGCGCCGGAGGAAAGAUGGAAGACUACCA… 710 nt 0.4352
NM_006519.4 NCBI
ACUCAGGGAGCCGGAGGGGACGCGCCGGAGGAAAGAUGGAAGACUACCA… 730 nt 0.4342
Summary

This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Forensic Context

A study in humans demonstrated that the DYNLT1 is significantly upregulated in sepsis patients compared to healthy controls [Leng et al. DOI:10.1186/s12865-025-00702-x].