Basic Information

Symbol
AGO3
RNA class
mRNA
Alias
Argonaute RISC Catalytic Component 3 EIF2C3 HAGO3 Eukaryotic Translation Initiation Factor 2C, 3 Protein Argonaute-3 FLJ12765 Eukaryotic Translation Initiation Factor 2C 3 Argonaute 3, RISC Catalytic Component EC 3.1.26.N2 Argonaute 3 Argonaute3 EIF-2C 3 EIF2C 3 HAgo3
Location (GRCh38)
1:35930696-36072500
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_024852.4
Sequence length
19660.0 nt
GC content
0.3887

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
- kcal/mol
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
-

Transcripts

ID Sequence Length GC content
NM_024852.4 NCBI
AGGUCGGCGGCGGCGGCCCGCAGUCGUGGAGGAGCGGUGGGAGCGUCGG… 19660 nt 0.3887
NM_177422.3 NCBI
AGGUCGGCGGCGGCGGCCCGCAGUCGUGGAGGAGCGGUGGGAGCGUCGG… 19402 nt 0.3875
Summary

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the AGO3 is essential for male fertility, with its loss causing meiotic arrest of spermatogenesis [Wang et al. DOI:10.1038/s41580-022-00528-0]. A study in Drosophila melanogaster demonstrated that mutation of the Argonaute 3 protein, a PIWI-clade Argonaute, leads to transposon upregulation in fly heads, indicating its functional role in somatic transposon silencing within neural tissue [Ross et al. DOI:10.1038/nature12987].