Basic Information

Symbol
ECRG4
RNA class
mRNA
Alias
ECRG4 Augurin Precursor Augurin C2orf40 Esophageal Cancer Related Gene 4 Protein Esophageal Cancer-Related Gene 4 Protein Chromosome 2 Open Reading Frame 40
Location (GRCh38)
2:106063246-106078155
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_032411.3
Sequence length
753.0 nt
GC content
0.4993

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-208.00 kcal/mol
Thermodynamic ensemble
Free energy: -221.49 kcal/mol
Frequency: 0.0000
Diversity: 169.81
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....(((...(((...((....))..))).((((......))))((.....)).......((((.((((((...(((((((((((...((((((.((((.........)))).))..))))(((((((((((((.((......)).))))).((((((((...(((........)))...)))..((((((........))))))..(((((((((....((....))....))))....)))))..(((((........))))).))))).))))))))....)))))))))))...)))....))).))))(((((((.(((((((((((((..(((.(((((((....(((((((((.((...(((........)))....)).))))...((.(((((..((((.........))))..))))).)).....)))))))))).)).)))..))))...)))).((.((((((.....)))))).))(((((....((((((......)))).)).....)))))....)))))..))))))).....((.....))....((((((..((((......)))).((((((.....(((....((((((((.......))))))))......)))......))))))........))))))...........((((.(((((.(....).)))))))))(((((((......((((....))))......))))))).......)))...
Thermodynamic Ensemble Prediction
.....{{{.,,({{...((....,},.}||.((((......}})}{{.....||......,(({(,(((,{(,,,(((((((((((.,.(((({(,((((.........)))).}).,))))(((((((((((((.((......)).))))).((((((((.,.(((........)))...))),.((((((........)))))).,{((((((,(...,,(....,}},.,}}}}.,,.))))}..(((((.{.....,))))).))))).))))))))..,.)))))))))))...)))...,))).))))||||{{{.(((((((((((((..(((,,,(((((....(((((((((.((...(((.,......)))....)).))))...{{.(((((..((((.........))))..))))).}}.....)))))))))).,).)))..))))...)))}.{{.((((((.....)))))).||(((((,{..((((((......)))).)}.,...)))))...,)))))..))))}}}..,,,{,..,,.}},,,,{{||||..{{{{......)))).((((((.....(((....((((((((.......))))))))......)))......))))))........)})))).....,,,...,,|,.{{{{{{.||||,.|{|||}{{|{((.....}}}}}}.....,}}},}},.,,.))))))}}},....,},...

Transcripts

ID Sequence Length GC content
NM_032411.3 NCBI
ACCCCUCUCCCGCGCCCGGUUCUCCCUCGCAGCACCUCGAAGUGCGCCC… 753 nt 0.4993
Summary

Enables neuropeptide hormone activity. Involved in neuropeptide signaling pathway; positive regulation of hormone secretion; and vasopressin secretion. Located in apical plasma membrane; dense core granule; and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the ECRG4 is expressed in activated fibroblast clusters CF5/CF6 following myocardial infarction, as identified through single-cell sequencing analysis [Bian et al. DOI:10.3892/mmr.2025.13680].