Basic Information

Symbol
EEF1B2
RNA class
mRNA
Alias
Eukaryotic Translation Elongation Factor 1 Beta 2 Elongation Factor 1-Beta EEF-1B Alpha EF-1-Beta EEF1B EF1B Eukaryotic Translation Elongation Factor 1 Beta 1 EEF1B1
Location (GRCh38)
2:206159585-206162932
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001959.4
Sequence length
808.0 nt
GC content
0.4703

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-237.80 kcal/mol
Thermodynamic ensemble
Free energy: -252.62 kcal/mol
Frequency: 0.0000
Diversity: 234.62
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((((((((.....((((((((((((.((.....)).))))))........((((((((((((..((((......))))..((..(((((((((....)))))..))))....))((.(((((((.........))))))).))......((((((((.....((.((((....)))).)).)))))))).(((((((((((((((((((((((((..((((.......(((((.....(((((((((((.............((((......))))...(((((...((((.(((((.......))))).))))....))))).)))))))))))..)))))..))))..)))).))).....((((..(((((.......((((..(((((((..(((....))))))))))..))))....(((....((((((((.......(((((.((...................((((......(((..((((((.(((((..((((((((....))))).)))..)))))...)))))).)))...))))..........((((((.......))))))..))))))).))))))))...))))))))..)))).........))))))))..........)))))))))).((((.(.(((...(((......)))..)))).))))))))).)))))))..))).)))...)))))......((((.((((....))))))))........(((((((..(((((...)))))..))).))))............)))))....
Thermodynamic Ensemble Prediction
.{((({(({((,,,,{((((((((((((.{{.....}).)))))),.....,{(({((((((((({.((((.....,|}}|,,,{..(((((((((....))))}.,)))),,..||((.(((((((.,,...,,.))))))).)).,..,.((((((((..,.,|{.{{{{,|,,}}},..,.)))))))).(((((((((((((((((((((((((..((((.......(((((.{..,({(((((((({.............((({......}))}...(((((...((((.{((((.......))))}.))))....)))}),)))))))))))..)))))..))))..)))).))).,,.,{,((.,(((((.,..,..(,((,.((((((({.,(({...,,|,,,,,},..,}},.}}}.,|}}}}|||{|||,,..,...||||}}||..........,{.,,....((((......(((..((((((.(((((..((((((((....))))).)))..))))).,.}))))).)))...))))....,,.,,.((((((.......)))))).,||}}}},,))}.}}|||,,|||},}},..,,}}}}}}},}..))))))))..........)))))))))),,,}}))}})))}}},|},...,}}}}},,}|,,,,,}}}))|}||||||..,,)}))),..})))}...,,.((((,((((....)})))))).,,,,,,.{{({(((..{{{{{...))))),.))).})}}........,...)))))....

Transcripts

ID Sequence Length GC content
NM_001037663.2 NCBI
AGCCUCGAGGCCGGGCGUCUUCGGUCAUCUCCGGCGCUUCUAGGGCUGG… 866 nt 0.4885
NM_001959.4 NCBI
CCUUUUUCCUCUCUUCAGCGUGGGGCGCCCACAAUUUGCGCGCUCUCUU… 808 nt 0.4703
NM_021121.4 NCBI
AGCCUCGAGGCCGGGCGUCUUCGGUCAUCUCCGGCGCUUCUAGGGCUGG… 820 nt 0.4793
Summary

This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mouse cardiac mesenchymal stem cells demonstrated that overexpression of HDAC11 induced transcriptional reprogramming, activating cell cycle pathways and promoting proliferation, while the EEF1B2 was identified as a downregulated hub gene in this regulatory network [Zhang et al. DOI:10.3390/biom15050662].