Basic Information

Symbol
EEF1D
RNA class
mRNA
Alias
Eukaryotic Translation Elongation Factor 1 Delta EF-1D Eukaryotic Translation Elongation Factor 1 Delta (Guanine Nucleotide Exchange Protein) Elongation Factor 1-Delta Antigen NY-CO-4 EF-1-Delta FLJ20897 EF1D NEDTCHAL FP1047
Location (GRCh38)
8:143579697-143599541
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Individual identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001130053.5
Sequence length
2090.0 nt
GC content
0.6464

Transcripts

ID Sequence Length GC content
NM_001130053.5 NCBI
CUCCCUUUCAUCAGUCUUCCCGCGUCCGCCGAUUCCUCCUCCUUGGUCG… 2090 nt 0.6464
NM_001130055.4 NCBI
CUCCCUUUCAUCAGUCUUCCCGCGUCCGCCGAUUCCUCCUCCUUGGUCG… 1161 nt 0.5978
NM_001130056.5 NCBI
CUCCCUUUCAUCAGUCUUCCCGCGUCCGCCGAUUCCUCCUCCUUGGUCG… 913 nt 0.6046
NM_001130057.4 NCBI
CUCCCUUUCAUCAGUCUUCCCGCGUCCGCCGAUUCCUCCUCCUUGGUCG… 1454 nt 0.6314
NM_001195203.4 NCBI
CUCCCUUUCAUCAGUCUUCCCGCGUCCGCCGAUUCCUCCUCCUUGGUCG… 928 nt 0.6024
NM_001289950.4 NCBI
CUCCCUUUCAUCAGUCUUCCCGCGUCCGCCGAUUCCUCCUCCUUGGUCG… 982 nt 0.6029
NM_001317743.4 NCBI
CUCCCUUUCAUCAGUCUUCCCGCGUCCGCCGAUUCCUCCUCCUUGGUCG… 910 nt 0.6044
NM_001330646.3 NCBI
CUCCCUUUCAUCAGUCUUCCCGCGUCCGCCGAUUCCUCCUCCUUGGUCG… 1382 nt 0.6339
NM_001960.7 NCBI
CUCCCUUUCAUCAGUCUUCCCGCGUCCGCCGAUUCCUCCUCCUUGGUCG… 985 nt 0.6030
NM_032378.7 NCBI
CUCCCUUUCAUCAGUCUUCCCGCGUCCGCCGAUUCCUCCUCCUUGGUCG… 2207 nt 0.6434
Summary

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]

Forensic Context

A study in humans demonstrated that the EEF1D was differentially expressed between monozygotic twins, belonging to the least variable category of housekeeping genes, and was also identified as a highly expressed housekeeping gene with a low coefficient of variation across individuals [Sharma et al. DOI:10.1152/physiolgenomics.00228.2003]. In mice, research showed the EEF1D was down-regulated in kidney tissue at 8 and 24 hours following whole-body irradiation, with a fold change of 0.516, indicating its role in the tissue-specific transcriptional response to ionizing radiation [Zhao et al. DOI:10.1158/1078-0432.CCR-05-2418].