Basic Information

Symbol
EIF3K
RNA class
mRNA
Alias
Eukaryotic Translation Initiation Factor 3 Subunit K PLAC-24 PRO1474 HSPC029 EIF3S12 PTD001 ARG134 M9 Eukaryotic Translation Initiation Factor 3, Subunit 12 Muscle-Specific Gene M9 Protein EIF-3 P28 Eukaryotic Translation Initiation Factor 3, Subunit K Eukaryotic Translation Initiation Factor 3 Subunit 12 Muscle Specific EIF-3 P25 EIF3-P28 MSTP001 PLAC24 EIF3k
Location (GRCh38)
19:38619055-38636959
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_013234.4
Sequence length
772.0 nt
GC content
0.5350

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-251.60 kcal/mol
Thermodynamic ensemble
Free energy: -265.83 kcal/mol
Frequency: 0.0000
Diversity: 262.38
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
......((((((.(((((....)))))..(((((.((((.(((...((((.((((...((.(.(((..((.(((........((((..(((((..(((.....(..(((..((((.((.(((.((((.(((((((....)))))...))))))))).)).))))..)))..)....)))..)))))...))))(((......))).((.((((((((.......(((((...((((.(((...)))))))...)))))..)))))))).))..))).))..))).).)).)))).))))...)))..((((((.....((((........))))))))))........)))).)))))........))))))......(((((.(((((......(((((.(.((((((((.((((.......)))).).))))))).))))))((((((....(((((.((((.((((.((....)).)))).))))....)))))....))))))............((((.....))))(((((.((((..(((((..(..(((((.((((((.((((((.((((((.((.((((((.....(((......))).....))))))..)))))))).)))(((((((((....)))))).(((.......).))......)))....(((((((((((........)))).))))))).))))))))).)))))..)..)))))....))))))))).....))))).))))).......
Thermodynamic Ensemble Prediction
.{{{{{{(({{{.(((((....)))))..(((((.((((.(((...((((.((((..,((,{.|((,{((|(((.,..|||.((((..{((((..(({...,.{.,(({..((((.((.(((.(((,{(((((((....)))}}...))))))))).)).))))..))).,).|..}})..))}))...)))}(((......))).,{.{{{((((({,....,||||{,,,{({(((((...)))))}}...}})))}})),,}}))})).||||.,,..}}}}),),.)))).))))...)))..|||{({|.,.|((((........)))))|,,)}}}},,...)))).)))))........))}}}}......(((((.((((({(((((,((((.,.((((((((.,,,(,,,,.,{||||.|||},}}}),)}))))}|,{,.....{((((.(((({(,{{,{,....|{(({,{(((((.(((((((|...(((((((((({(((,,((.((((.....)))).)))))}.}{{{(((((((((((((,,{(((.(....}.)))}))))).))))))))....}}}}})))))))).....((((,.,...)))).}..,))}}}})))))))))).....}})),.},,,,,.,..||,.,|}}}}|}(((((((,(((.,,.....}})}.)))))))))))),..))}))))}..))}))))),.}))))))))},..,,.}}))).))))).......

Transcripts

ID Sequence Length GC content
NM_001300992.2 NCBI
CUCUUCCUGUUCCCGUCCUUGAGGACGCCGUGCCGGGUCAGUGUUAGCC… 694 nt 0.5317
NM_001308393.2 NCBI
CUCUUCCUGUUCCCGUCCUUGAGGACGCCGUGCCGGGUCAGUGUUAGCC… 762 nt 0.5354
NM_013234.4 NCBI
CUCUUCCUGUUCCCGUCCUUGAGGACGCCGUGCCGGGUCAGUGUUAGCC… 772 nt 0.5350
Summary

The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008]

Forensic Context

A study in human postmortem dorsolateral prefrontal cortex demonstrated exploratory evidence for differential exon usage of the EIF3K in major depressive disorder [Pantazatos et al. DOI:10.1038/mp.2016.130]. A study in rats demonstrated that the EIF3K was differentially expressed in the hypothalamus during hypothermia, with 16 tags in control and 4 tags in hypothermic samples, indicating a higher expression in normal conditions [Takamiya et al. DOI:10.1016/J.Jflm.2012.04.017].