Basic Information

Symbol
EIF4EBP1
RNA class
mRNA
Alias
Eukaryotic Translation Initiation Factor 4E Binding Protein 1 PHAS-I 4E-BP1 Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1 Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 EIF4E-Binding Protein 1 4EBP1 BP-1
Location (GRCh38)
8:38030512-38060365
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004095.4
Sequence length
827.0 nt
GC content
0.6288

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-325.60 kcal/mol
Thermodynamic ensemble
Free energy: -340.92 kcal/mol
Frequency: 0.0000
Diversity: 211.60
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((((((((.((((.(((((((..((...((((.(..(((.((((((((((((..(((((..(((.......((.(((....))).))........((((((((((.((.((..((((((......((((.((((.(........).)))).)))))))))))).))))))))))))..((((((((.((((..((((.((.((((..(((((....))))).))))...(((.(((((((.....(((((((..(((.....))).((((...((((((((.((..........)).))).))))).))))......(((((......))).))....((((...........))))))).))))....)))))))..)))(((((................)))))(((.((((.........(((((((((((((.....)))))).)).)))))....(((..(((((((((......)))))..)))).)))...(((.((((((.....)))))))))....))))..)))...((((....)))).....((.....))....))..))))...)))).)))))))).))).)))))..)))))).)))....))).)))..)))))...)).))))).))))))..((((.((((((.((...........))))))))...((((........))))..)))))))))))))(((((........))))).(((((((.(((.((((((((((....))))....(((((((....))).))))......))).)))..))).)))))))......
Thermodynamic Ensemble Prediction
..(((((((((.((((.(((((((.((.(((((((((....,,|,.((((((((,.{({{,.,{(.(((((({.((((((,....}},}||.{{(.{{((((((((((.((.({.{((((({.....{((((.((((.{........}.)))).)))))))))))}.))))))))))))})})|)||..(((((...(((......))}...)))))..,(((((((.{..((((.(((((((.....(((((((..(((.....))).{{{(,,,(((({(((.({,,.......,)}.})}.))))).}))),.....(((((......))).))....((((.,........,))))))).))))....)))))))..)))).}.))))))}...{(.,,,||,...||{|||.}}.,..,,..((((((({{{{((|,,.,)))))).)).))))).,..(((..(((((((((......)))))..)))).)))..,))).}))))))||...,,})}|||,,....,,,......))))}..))))))))...,{...,{|.....,.},})}...))))},)))))).))))..))).(((((((({{{{{{...))}.}}}.|||||{,..{|,....}})),),,..})}..((((((.((...........))))))))...,,.......))))))))}))).)))))))))(((((.,....,.))))}.(((((((.(((.((((((((((....}}}},,,,(((((((....})).))))......)))}}))..))).)))))))......

Transcripts

ID Sequence Length GC content
NM_004095.4 NCBI
AGGGCAGCGAGAGGUUCGCGGGUGCAGCGCACAGGAGACCAUGUCCGGG… 827 nt 0.6288
Summary

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008] CIViC Summary for EIF4EBP1 Gene

Forensic Context

A study in *Phormia regina* maggots identified the EIF4EBP1 as an RNA marker differentially expressed between feeding and wandering behaviors specifically at 120 hours post-hatching [Lin et al. DOI:10.1371/journal.pgen.1011948].