Basic Information

Symbol
ELOB
RNA class
mRNA
Alias
Elongin B TCEB2 SIII Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) RNA Polymerase II Transcription Factor SIII Subunit B Transcription Elongation Factor B Polypeptide 2 Transcription Elongation Factor B Subunit 2 Elongin 18 KDa Subunit Elongin-B SIII P18 RNA Polymerase II Transcription Factor SIII P18 Subunit Epididymis Secretory Sperm Binding Protein Elongin, 18-KD Subunit EloB
Location (GRCh38)
16:2771414-2777290
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_007108.4
Sequence length
974.0 nt
GC content
0.5986

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-371.00 kcal/mol
Thermodynamic ensemble
Free energy: -387.64 kcal/mol
Frequency: 0.0000
Diversity: 207.48
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((....))).((.(.((.((((((((((((((((((((((.((((((((.....)))).)))).))).............(((((((((((........)))).(((((((((((........((.((((((((((((((((((...((((((..(((.....))).))))))...)))))).))..)))...)))))))))....(((((..(((((.((((((((.(((((...((((.(((((((.(((....)))...)))(((((((.....(((...((((((((((...)))...))).))))...)))....)))))))))).).))))...))).)).)))))))...).))))).....))))).....))))..))))))).)))))))........((((....(((((................)))))...)))))))))))))))))....((((.(((.....))).)))).(((((.....))))).((((..(((((((.(.((((....(((..((((((.(((((((((((...((((....(((((((((......((((...((..(((((((((.(((....((((.....(((...))).....)))).))).)))..))))))..))..)))).......)).)))))))..))))..))))..))).)))).)).))))..)))..))))))))))))))))...(((((....))))).((((....(((((((..(((.....((((((((..((((((.((.(((.((......))))).))...))))....(((.(((((((((((....)))))))..)))).))).......(((...))).....(((((......)))))......)))))))).))....))))))))))...))))..)))))).)).).))...........(((....)))...
Thermodynamic Ensemble Prediction
{(({{..})),((.(.((.((((((((((((((((((((((.,(((((((.....)))).)))}.))).....,.......{((((((((((.{....}.)))).((((((((((({...,...((.((((((((((((((((((...((((((..(((.....))).))))))...)))))).}}..}))}}.)))))))))..,.(((((,,(({((,{(((({{{.,,{({...{{({.,(((({|.{((|,,.}}}...)))||||{((.....{((((.(((((({{({...|}|...,}),))))..})))....)))))))},|,..|||},,,||,,|,.||}}}}}.,,..))))),,.,,)}})),,..,))))..})))))).))))))).......,({{(,,{.{{(,(,,,,.......,,.,}))),)},,))}})))))))))))))....((((.(((.....))).)))).(((((.....))))).{(({..(((((({,(.((((,,..{((..((((((.(((((((((((...((((....(((((((((......((((...((..((((((,{(.(((....((((...,.(((...))).,...)))).))).)),..))))))..))..)))).......)).)))))))..))))..)))}.,))).)))).)).))))..))),.)))))))))))))))}...{{{{,....,}},,.((((,{{,{((((({..(((.....{{(((((,.{((((((.((,(((.{{,..,,.}}|||,}}...}}}}....{{,.(((({{(((((....))))))}..)))).))).......(((...)))..,..(((((......)))))......)})))))).}}....))))))))))}}.))))..)))))).)).).)}...........(((....)))...

Transcripts

ID Sequence Length GC content
NM_007108.4 NCBI
GCGGCUGCGCCGGCGCGUCGAGGGGAGAGGCAGCAGCCGCGAUGGACGU… 974 nt 0.5986
NM_207013.3 NCBI
GCGGCUGCGCCGGCGCGUCGAGGGGAGAGGCAGCAGCCGCGAUGGACGU… 585 nt 0.6068
Summary

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

Forensic Context

No relevant information is available at the moment.