Basic Information

Symbol
AHNAK2
RNA class
mRNA
Alias
AHNAK Nucleoprotein 2 C14orf78 Protein AHNAK2 Chromosome 14 Open Reading Frame 78 KIAA2019
Location (GRCh38)
14:104937244-104978374
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_138420.4
Sequence length
18335.0 nt
GC content
0.5852

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
- kcal/mol
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
-

Transcripts

ID Sequence Length GC content
NM_001350929.2 NCBI
AGUUGGGAUCUUCGCUUCUGGGCCAGUUGGGAGAGCGUCUGUAGCUUCC… 18195 nt 0.5829
NM_138420.4 NCBI
AGUCCGAGGUCGGCCGCCCGCGGCAGCGCAGGGCAGCGGGGCAGAGCGC… 18335 nt 0.5852
Summary

This gene encodes a large nucleoprotein. The encoded protein has a tripartite domain structure with a relatively short N-terminus and a long C-terminus, separated by a large body of repeats. The N-terminal PSD-95/Discs-large/ZO-1 (PDZ)-like domain is thought to function in the formation of stable homodimers. The encoded protein may play a role in calcium signaling by associating with calcium channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

Forensic Context

A study in humans demonstrated that the AHNAK2 was upregulated during long-term weight loss (0 to 12 months) in weight losers within subcutaneous adipose tissue [Bollepalli et al. DOI:10.1038/ijo.2017.245].