The protein encoded by this gene is an intracellular fatty acid-binding protein that participates in the uptake, intracellular metabolism, and transport of long-chain fatty acids. The encoded protein is also involved in the modulation of cell growth and proliferation. This protein binds saturated long-chain fatty acids with high affinity, and may act as a lipid sensor to maintain energy homeostasis. [provided by RefSeq, Aug 2017]
Forensic Context
A systematic review of postmortem human brain studies found that plasma levels of the FABP2, a marker of blood-brain barrier permeability, were increased in adolescent patients with major depressive disorder and anxiety [Yamamoto et al. DOI:10.3390/Ijms25115750].