Basic Information

Symbol
FABP6
RNA class
mRNA
Alias
Fatty Acid Binding Protein 6 I-BABP I-15P ILLBP ILBP Gastrotropin I-BALB I-BAP ILBP3 Fatty Acid Binding Protein 6, Ileal Ileal Bile Acid Binding Protein Illeal Lipid-Binding Protein Ileal Lipid-Binding Protein Intestinal 15 KDa Protein GT Intestinal Bile Acid-Binding Protein Fatty Acid-Binding Protein 6
Location (GRCh38)
5:160187363-160238735
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001445.3
Sequence length
496.0 nt
GC content
0.5524

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-163.30 kcal/mol
Thermodynamic ensemble
Free energy: -172.17 kcal/mol
Frequency: 0.0000
Diversity: 103.50
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...........((((..(((.(((((.(..(((((((..((((((((....(.((((((((...(((...(((((..((((((..(((.((..((((((.....))))))..)).)))....)))))).........)))))...))).(((.((((...........)))).)))....((((((((.(((((......)))))..)).))).)))))))))))..((.((.((((((.......)))))))).)).............)....))))))))..)).......)))))..).))))).)))(((((((...(((((((((............)))))))))..((((....((((((((.((...(((((((.((...)).)))))))....)).)))))))).....)))).......(((((.......))))).))).)))).(((.........)))..................))))..
Thermodynamic Ensemble Prediction
..,,,{..{{((((({.(((.(((((.(..(((((({..((((((((...,,,((((((((..,{{{...,((({..((((((.,(((.((..((((((.....))))))..)).)))....)))))).},,.....))),,..((((((({.((((..{,...,,..}))),)))....((((((((.(((((......)))))..)).))).))).,)))))...{{.((.((((((.,....,)))))))).}))))))..,,,.,.,....))))))))..},......})))))..).))))).)))|||,|||,,.(((((((((............}))))))))..{((({.,.{{((((((.,,..{((((((({.{..|}),)),,,}},}|}}}.}))},}}},|.|.}},)}......(((((.......))))).|||.,},,.|||,}},....,)))}}........,},,....,))...

Transcripts

ID Sequence Length GC content
NM_001040442.1 NCBI
CAUUGCAGACUUUGCACCUCUGGCUCCAGGGAGCUCACAGGCAGGGGCU… 672 nt 0.5446
NM_001130958.2 NCBI
GAUUACUUUGAAGGGACUAGAAGGAGGACACAGGGUCCUGGAGGAAGGC… 723 nt 0.5477
NM_001445.3 NCBI
ACCACCCAUUCUCCUCAUCCCUCUGCUCUCUGGCCUCCAGCCUCCCAGC… 496 nt 0.5524
Summary

This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the FABP6 is expressed in small intestine tissue, with an average read count of 36,487 and detection in three of four samples, as part of a targeted 46-plex mRNA assay for definitive organ identification [Hanson & Ballantyne DOI:10.3390/genes8110319]. The review further notes the FABP6 serves as a marker for intestine identification within forensic transcriptomics for tissue tracing [Lei et al. DOI:10.1093/gpbjnl/qzag007].