Family With Sequence Similarity 107 Member A
DRR1
TU3A
Down-Regulated In Renal Cell Carcinoma 1
Actin-Associated Protein FAM107A
Family With Sequence Similarity 107, Member A
Down-Regulated In Renal Cell Carcinoma
Protein FAM107A
Protein TU3A
Predicted to enable actin binding activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; negative regulation of focal adhesion assembly; and regulation of cytoskeleton organization. Located in several cellular components, including focal adhesion; ruffle membrane; and stress fiber. [provided by Alliance of Genome Resources, Jul 2025]
Forensic Context
A study in rhesus macaques demonstrated that whole-thorax irradiation induced significant transcriptomic dysregulation in lung tissue, where the FAM107A was identified as one of the top downregulated transcripts among common differentially expressed genes in irradiated animals compared to sham controls [Priyanka Thakur et al. DOI:10.1016/j.ijrobp.2021.03.058].