Fc Gamma Receptor IIb
CD32
FcgammaRIIb
FcGRIIB
CD32B
FCG2
Fc Fragment Of IgG, Low Affinity IIb, Receptor For (CD32)
Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B
Fc Fragment Of IgG, Low Affinity IIb, Receptor (CD32)
Fc Fragment Of IgG Receptor IIb
IgG Fc Receptor II-B
Fc-Gamma RII-B
Fc-Gamma-RIIb
FcRII-B
FCGR2
IGFR2
CDw32
Low Affinity Immunoglobulin Gamma Fc Region Receptor II-C
Fc Fragment Of IgG, Low Affinity II, Receptor For (CD32)
IgG Fc Receptor II-C
Fc-Gamma RII-C
Fc Gamma RIIb
Fc-Gamma-RIIc
CD32 Antigen
FcRII-C
FCGR2C
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] CIViC Summary for FCGR2B Gene
Forensic Context
A study in C57BL/6J mice using a closed head weight-drop model demonstrated that mild traumatic brain injury induces significant transcriptional upregulation of the FCGR2B in the ipsilateral neocortex three days post-injury, with a 3.0-fold increase, indicating its role in the inflammatory and immune response to neural trauma [Israelsson et al. DOI:10.1089/neu.2008.0676].