Basic Information

Symbol
FCGR3A
RNA class
mRNA
Alias
Fc Gamma Receptor IIIa FcgammaRIIIa FcGRIIIA CD16a FCGR3 CD16 FCG3 Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a) Fc Fragment Of IgG Receptor IIIa IgG Fc Receptor III-A IgG Fc Receptor III-2 Fc-Gamma RIII-Alpha CD16a Antigen CD16-II IGFR3 Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A/III-B Recombinant Low Affinity Immunoglobulin Gamma Receptor III-A Fc Fragment Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16) Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B Fc Fragment Of IgG, Low Affinity III, Receptor For (CD16) Immunoglobulin G Fc Receptor III Fc-Gamma Receptor III-2 (CD 16) Neutrophil-Specific Antigen NA Fc-Gamma Receptor IIIb (CD16) Fc Gamma Receptor III-A Fc-Gamma RIIIa Fc-Gamma RIII FcgammaRIIIA FCGRIII FCRIIIA FcRIIIa FCR-10 FCRIII FcRIII FcR-10 IMD20 CD16A
Location (GRCh38)
1:161541759-161550968
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000569.8
Sequence length
2100.0 nt
GC content
0.4538

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-611.60 kcal/mol
Thermodynamic ensemble
Free energy: -653.89 kcal/mol
Frequency: 0.0000
Diversity: 612.74
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((((((((((((((.((.((((.((((.((((.(((((.......(((((((((((((((((((((((.(((.(((...))).)))((((((.......((((((((....((((((((((((((((.....))).)))))...(((((((((((((((((((.((((..(((.....))).))))((..((((...((.((((((.(...((((((((..(((.((((....(((((.(((....)))...))).))........(((((......)))))....)))))))..)).)))))).).))))))))....))))..)).((((((((.....((.....))....)))))))).....((((((..((((((..((.(((.....((..((((((((.......(((.(((((((((((.(((......))).)))).....))).)))).)))))))))))..))..))).))))))))..)))))).........(((((...(((.(((((................))))).)))...)))))........))))).....)))))(((((((.........))))))))))))))))....((((((((((((.((((((((..(((.(((((((((((.(((..((.((((.............))))))....))))))))(((((((........))))))))))))).............)))..)))))...........))).)))))))..))))).....(((.....)))))))))))..((((........)))).......................((((((((...))))))))....)))))))))))))).(((..(((((.......)).)))..)))..(((((((((((((((.(((((............(((.....(((.(((((........(((((((((.....((.(((((((.((((((.(((.((((.........(((..((((((((.((((((....)))((((.((((((......((.(((((....))))))))))))).....))))..(((((((.((((((((....(((((((((((..........)))((((((....))))))..............))))).)))...........(((.((((...(((((.............)))))...)))))))............)))))))).)))))))((((((...))))))....)))))))))))..)))..)))).))))))))).))))..((((((((....(((.(((..((((......((((..((((((((....)))))...)))..))))..))))..))).))).....))))))))))).)).......))).....))))))..........)))))))))))(((((((((.(((...((((((.....))).))).......))))))))))))...(.((((((.((.....)).)))))).)))))).))))))))...)))))))..)))))))))...((.(((((((........))))...))).)).)))))))))))).)).........(((((.........))))).)))))..))))...).))))))))).))...))))).)))).(((((((((..((((((((((((.((((((((((......((((((((.(((...(((((((..((......))..)))))))...))).))))))))..(((.(((((.((....((((((((.........(((((......))))).))))))))..)).))))).)))(((...(((((....))))))))..(((.((.((((.(((.......))).)))).)).))).........((((((............((((.((((..(........)..))))..))))))))))..))))))..)))).)))))))))).))...))))))..)))..(((.....)))..((((.....)))))))))...................
Thermodynamic Ensemble Prediction
..((((((((((((((((.((.(({{{((((.((((.(((((..,,...,{{{(((((((((((((((((((.(((.(((...,)).))|((((((.......((((((((,,,.{((({(((((((((((.....))).))))),..(((((({{((((((((({,.{{({.,(({,,..,|}}.}}}|{{{{(((({..{{.{{((((,,...{((((({(({(((((....))}}}}}}.|{|,...})),},}.|{(|,,.,,,..(((({..,,..}}}}},},,)}}})))},)).)))))),),)}))))))},.,)),}.{|,.((((((((....,{{.....))....))))))))..||.((((((..((((((,.{{.(((,....{{||||{{{|||,}}.,,.(((.(((((((((((.(((......))).)))}....,))).)))).)}}}}}})))}..}}..|||,||||}}}}..}}}}}}.........(((((...,{(,{{(((,.{,,.......,.,.})))}.)))...))))).....|||,},||,...,},}},({(((((.{....,.,)))))))))))))))),,..,{{|||{|||{{,((({((({..{,,.{(({{{{{{,..|||.|{||||||}},}|,.,,....,.,,,,.,{{},,}))}}(((((((........)))))))))))))..,{{.,,,,,.,|}},.|||||,........,}})),))}}}))...}}}},....(((.....)))})))))))..{(((........)))}||,..,....,}}..........((((((((...))))))))....)))))))))))))).(((..(({({.....,,}}.)))..)))..(((((((((((((((.(((((,,.........,{{{......,..(((({{,,,,,,(((((((({,...{{{,{,{(((((.((((((.(((.((((.........(((..((((((({{((((((....|}},{({.((((((......{{.(((((....)))))}})))))).,...||||..(((((((.(((((((({{{((,,{((,.{({..........}}}{(((((....)))))}....,,,.......}))}}.)))},.,,,,{{,.,{|}||||,,}|||{,..........||.}|||,...,,,,,)),,,,,,......}))))))).)))))))((((((...))))))...))))))))))))..)))..)))).))))))))).)))},..,|{((||,....,,,.{{..,,)},}},..,,|},,|||||,,,,}}}}.||||}}||},}})}},}))),})))||||.,,.||||{,},,}})}),.......,}}}...,,},,|||.|{{.{,....}},))),}))(((((((((.(((...((((((.....)))},)).......))))))))))))...{.((((((.((.....)).)))))).}})))).))))))))...)))))))}.)))))))))...|,.,{(((((........))))},,|}}.,,.)))))))))))),}}.........(((((.........))))).)))))..))))...),})))))))).))...)))))}})))}(((((((((..((((((((((((.((((((((({......((((((((.{((...(((((((..((......))..)))))))...})}.))))))))..(((.(((((.((....((((((((.,,.{{,...|||||,|,....}}}.))))))))..)).))))).))),|{|,.{((({....}))}}||...{((,((.((((.(((.......))).)))).)).)))}.,|{,,..{({{(({{........,|||,,.||||,}|}...,,,,)},)})}..})))}))))}..})))))..)))).)))))))))).))...))))))..)))..(((.....}}),,((((.....)))),)))}...................

Transcripts

ID Sequence Length GC content
NM_000569.8 NCBI
GUUUACUUCCUCCUGUCUAGUCGGUUUGGUCCCUUUAGGGCUCCGGAUA… 2100 nt 0.4538
NM_001127592.2 NCBI
AUUCUUGGUGCUGGGUGGAUCCAAAUCCAGGAGAUGGGGCAAGCAUCCU… 2412 nt 0.4598
NM_001127593.1 NCBI
GGAGCCCCGGCUCCUAGGCUGACAGACCAGCCCAGAUCCAGUGGCCCGG… 2204 nt 0.4560
NM_001127595.2 NCBI
AGCCCCGGCUCCUAGGCUGACAGACCAGCCCAGAUCCAGUGGCCCGGAG… 2153 nt 0.4617
NM_001127596.2 NCBI
AGCCCCGGCUCCUAGGCUGACAGACCAGCCCAGAUCCAGUGGCCCGGAG… 2150 nt 0.4619
NM_001329120.2 NCBI
AUUGUGAGAGUAACCAACGUGGGGUUACGGGGGAGAAUCUGGAGAGAAG… 2164 nt 0.4575
NM_001329122.1 NCBI
AUUCUUGGUGCUGGGUGGAUCCAAAUCCAGGAGAUGGGGCAAGCAUCCU… 2157 nt 0.4576
NM_001386450.1 NCBI
AUUGUGAGAGUAACCAACGUGGGGUUACGGGGGAGAAUCUGGAGAGAAG… 2161 nt 0.4577
Summary

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020] CIViC Summary for FCGR3A Gene

Forensic Context

A study in humans demonstrated that FCGR3A is expressed in non-classical monocyte clusters C7 and C8 and serves as a monocyte marker for cell type identification [Hua et al. DOI:10.1002/advs.202500457]. Another study in humans identified FCGR3A as a marker expressed in monocytes within penile cavernous tissue from patients with erectile dysfunction [Fang et al. DOI:10.3389/fendo.2022.874915]. A study in mice demonstrated that following clodronate liposome pre-treatment and controlled cortical impact injury, a distinct CD115+/Ly6Chi monocyte population emerges in circulation, which is associated with neuroprotection, blood-brain barrier stability, and improved cerebral blood flow [Erwin K. Gudenschwager Basso et al. DOI:10.1186/s12974-024-03032-8].