Basic Information
Symbol
FEV
RNA class
mRNA
Alias
FEV Transcription Factor, ETS Family Member
Pet-1
PC12 ETS Domain-Containing Transcription Factor 1
FEV, ETS Transcription Factor
Fifth Ewing Variant Protein
FEV (ETS Oncogene Family)
Protein FEV
FEV (Fifth Ewing Variant)
PC12 ETS Factor 1
HSRNAFEV
PET1
Location (GRCh38)
2:218981087-218985184
Forensic tag(s)
-
MANE select
Transcript ID
NM_017521.3
Sequence length
1406.0 nt
GC content
0.6679
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-587.80 kcal/mol
Thermodynamic ensemble
Free energy:
-607.61 kcal/mol
Frequency:
0.0000
Diversity:
475.47
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
........((((((..((((.(((((((((..((.(....((((.(((.....)))))))..)))..)))))))))((((((.(((...(((((........))))).(((.((.(((.(.(((........))))))))).))).....((.(((...(((..(((((...)))))..)))...)))))(((.....)))))).)))))).....)))).)))))).(((((((.(((.(((.......(((((..(((((((((....)))))))))))))).((((((((..((.....)).))))))))(((((((((...((((.(((((((((...((((..((....((((((((((((((((((((((((((.(.((..((.((.(.((........)).).)).))...))).))))))...................(((((((...((((.((((..((((((.((((................)))).)))))).(((......)))))))...))))..)))))))..((.(((((.((.((....)).)).))))).))..(((.(((((.((..........)).))))).))).((((((..(((......(((((...................)))))....)))))))))...(((((((((((.........))))))...)))))...((.((....)).)))))).)))))))))))))..))))).)))).)))))).)))...))))..(((((((((((..((.(((....))).))..)))))))))))..........(((((((.((((((((((.(((((......))))).))..........))))))))))...(((.(((((((.....)))))))))).))))).))))))))).......((((((.((((..((((........))))((((((((((..((((.................(((....(((((((...((((........))))......((((((((((.....))))))))))..........((((((((...(((((...(((((((((.....(((....)))....)))))..(((....)))....)))))))))..))))))))................(((((......))))).)))))))....))).....((..((((....))))..))..((((........))))((((((((((.((((((.......)))))))))).))))))((((.....)))).....(((((...)))))....)))).)))))))))).........))))))))))))).))).)))))))..................((((....))))...
Thermodynamic Ensemble Prediction
........((((((,,(((,.(((((((((..((.(....((((.(((.....)))))))..,))..))))))))){{{{{{.(((.,.(((((........))))).{{(,{{.(((.(,(((......,,||}}}}})).}}}.....{{.(((...(((..(((((...)))))..)))...)))))(((.....))))}),)))))),,,||||||,}}}}))}||||{{{.((({(((,..,..,((((|,,(((((((((....)))))))))))))).|||||{{{..((,,,..}}.}})))))}{{{{|||{{{,|||{(,(((((((((,,,(((,..(({{..(((((((((({((((((((({((((,.{.((..((.{{.{.{{........}}.}.)}.}}.{{||,.})))||..,,{{,.{{,,{{.....{{{((((..{((({.{(((..(({{{{,{{{|...||,,.........}|||.}||}}},{|||,||||||}||}|,..||}}..))))}}|,,((.(({((.((.{{.,,.)).)).))))).))..{||.|||||,|{......,}},)}.}))})|))}.||,..},.||{||.,,,((({{..............,,,..|||}|...,((|{(((((((,(((((((((.........))))},)))).,|||||||||||{{.{{||{|,|||}{|},,}))})))}....||||,||}|.||}|||,,||,.,,|||,.(({{{..,.))))}),))),)),})))},.}}..||||(({,....,|,,.}|{||||||||,||||,||}|||||},,,),)))},.))}..}}}....|||||||,,.,,}|||...|||||}}}}})..((((((.((.(((..(((((((,.......(((....}}}..(((((........))))))))))))))).)).))))))......}})}}}}))}|.|||,,||||||.,||}}}}}}}}}},{.....{((((((((((.....)))))))))},,........((((((((...((((({..((({(((({,..,.{(|,...,,,.,..}))))..{{{....}}}....}}}))))))..))))))))................{((((......)))))........,{{{{{{..{{{(({{.,,({,.,||{{{((((........)))).},(((((((......)).))))).}}}))))},..))))))),,))),)}},)))})))))}}}}))),,,,,,}|}}}}}},.((((((............))))))......))),))),),,||||.....}}}}.........||||..}})))),..
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| CUUGUCACCCGCGGUCGCUUCGGGCGGGGAUCGGUGCCACCGAGCGCAA… | 1406 nt | 0.6679 |
Summary
This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]
Forensic Context
No relevant information is available at the moment.