Basic Information

Symbol
FKBP1A
RNA class
mRNA
Alias
FKBP Prolyl Isomerase 1A FKBP-12 FKBP12 PPIASE PKC12 FKBP1 Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A FK506 Binding Protein 1A, 12kDa 12 KDa FK506-Binding Protein FK506-Binding Protein 1A Immunophilin FKBP12 PPIase FKBP1A 12 KDa FKBP Calstabin-1 EC 5.2.1.8 Rotamase FKBP12C FKBP-1A FK506-Binding Protein, T-Cell, 12-KD FK506-Binding Protein 1A (12kD) Protein Kinase C Inhibitor 2 FK506 Binding Protein 1A FK506-Binding Protein 12 FK506 Binding Protein12 FK506-Binding Protein 1 FKBP12-Exip3 Calstabin 1 PKCI2
Location (GRCh38)
20:1368977-1393164
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000801.5
Sequence length
1514.0 nt
GC content
0.4690

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-471.80 kcal/mol
Thermodynamic ensemble
Free energy: -497.82 kcal/mol
Frequency: 0.0000
Diversity: 412.92
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((..((....((.(((.....))).))...((((((.(((.(((.(((((.((...((((....(((((....((.(((((...))))).))...)))))))))...)))))))..)))))).)))).))......((((((.((((((((..((.......((((.((((....))))))))......))))))))))....(((((((((((((((((((....((((((((((.(((((((..(..((((.(.((((.((....(((((.....((((..........(((.((((((..((((((....)))))).)))))).)))....(((((..((.((..((((.(((.((((((..........((((((..((((((.(((.((((((..(((.(((........))).)))....)))))).(((((.....)))))((((....))))..(((....)))))).))))))..)))))))))))).)))...)))).........)).)).)))))....))))....)))))....)).)))))))))......)..))))))).)))..(((((((.((((....))))))))))).............................(((((((((...(((((((((((.......))))))(((((........)))))..........((((...(((.(((((((((((((((.((....((((((((........(((.(((((((((((((..((((((((.......((((((....((((((((...))))))))......)))))).)))))))).((.(((((.((((((....))...)))).))))).)).((((((.......(((((......)))))..))))))(((((........))))).............(((((((((((((((.((....)))))).))))))))))).)))))))))))))))).(((((........)))))....((((((......).)))))((((((((.....(((((((......))))))).......(((........)))................))))))))..))))))))........((((..((((......))))..)))).....)))))))))...............((((((((((.....)))))))))))))))))).)))))))...))))))))))))))(((((.(((((........(((((........)))))...))))))))))......)))))))..)))))))))))......)))))))).......((((....)))).))))))........))..))))...((((((((...((((((.......))))))...))))))))...(.(((((...........))))).).....((((....(((((....((..(((.......)))..))....)))))..))))
Thermodynamic Ensemble Prediction
(((({((({...{(,{({.....))).}},..((((((.(((.(((.(((({{((..{(((,,...(((((....((.(((((...))))).))...)))))})))}}.)))))))..)))))).)))).)).,,..,{{({(,,(({{{{,{,{((,,.,,.,{{{{.|{{{,,..||{||.{{{,,.,{{{.....{{|....|||((({((((((((((((.,{.(((((((((,.((,((({...}}}(((((((,(((((((((.,.......}))))..........(((.((((((..((((((....)))))).)))))).)))..........}}}}.)))||||.(((.((((((..........((((((,.((((((.(((.((((((..{{(.(((........))}.}}},.,.)))))),(((((.....)))))((((....))))..{{{....)))))).)))))).,)))))))))))).)))...||}}..,,,,..{({(,((,.,,,,}}.}))),})))}}}})},,}.})))))))))))},,,|..}}}}},,.,,,..(((((((.((((....))))))))))).....{{,,{{{{.....,,........}|,,|,,,,}}}}||}||||{{,,..,,,,,,)))}}{((((........)))),..,}||||.,|||..,}||}}||||||{{,{((((({(,..,,({{{(((,....,,.,((({(((((((((((((..((((((((.,{{.,..,{{{{....((((((({...})))))))..,...},}))).)))))))),(({(,(((.,,,|||..,,))}}.,,}},||,||{|,.((((({..,....(((((......))))),.})}}}}(((((........)))))..........,(.(((((((((((((((.((....)))))).)))))))))))})}}}}}}}}},,,,,,.{{{((,...,,,,}||||,,..((((({.,,...),))))){(((((((.....(((((((......)))))))....{{{(((........))).,,.............))))))))..,}}}},||{{{{{...((((..((((......))))..))))})).})})}}}}}|..,.........}..((((((((((.....))))))))))}}}}}}}}.}},}}},..,)}}}}}|}||,|||(((({,(((((.,,.....{{{((........}}}))...))))))))))...,,.}}}}}))||)))),,,))))....}}))))}))),....,,|{||,,,}})}),},..))},..}),)),..}))}.,,|(((((((...((((((.,....}))))))...)))))))}...|||||||.}}}},}}}}})))))}}}.,,.,||,}}}.|{|||...}||,,||,..|{{{{|||.....)}.})))),.....

Transcripts

ID Sequence Length GC content
NM_000801.5 NCBI
GCUGUUGGUCCACGCCGCCCGUCGCGCCGCCCGCCCGCUCAGCGUCCGC… 1514 nt 0.4690
NM_001199786.2 NCBI
GCUGUUGGUCCACGCCGCCCGUCGCGCCGCCCGCCCGCUCAGCGUCCGC… 1401 nt 0.4661
NM_054014.4 NCBI
GCUGUUGGUCCACGCCGCCCGUCGCGCCGCCCGCCCGCUCAGCGUCCGC… 779 nt 0.4917
Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]

Forensic Context

A study in human menstrual blood-derived stem cells (MenSCs) demonstrated that the FKBP1A is a differentially-expressed gene involved in the regulation of transcription and translation, and its expression was found to be down-regulated with increasing donor age [Chen et al. DOI:PMC4713568].