Basic Information

Symbol
FOLR3
RNA class
mRNA
Alias
Folate Receptor Gamma FR-G Folate Receptor 3 (Gamma) Folate Receptor 3 FR-Gamma Gamma-HFR FRgamma FRγ FRG
Location (GRCh38)
11:72114869-72141085
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000804.4
Sequence length
849.0 nt
GC content
0.5830

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-322.60 kcal/mol
Thermodynamic ensemble
Free energy: -335.27 kcal/mol
Frequency: 0.0000
Diversity: 263.73
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((.((.((.....(((((((..(((((((...)))))))..))))).)).....)))).)))....((((((((.((((((((((((((((.((((((((((((((.(.((((...((((((.(((((.(((((((.((..(.(((.........))).)..))))..............(((((.(..((....))..).))))).))))).))))).).)))))........(((.....)))(((((....(((((((((((.(((.....(((((((((((((..............((((.(((((......)).)))..))))......((((((((...(((((((..(((..((.....))..)))..((((...))))..)))))))..((((.((....(((((...((((.....)))).))))).)).))))(((.(....).)))...))).))))))))))))))..))))))).))))).((..(((....)))..)).......))))))....((((((((........)))).)))))))))))))))))))))))......((((...)))).....((((((..(((.........)))..))))))............))))).)))....))))..))))))))).))))))))((.((((((((((.....(((...)))(((((((((((((.((.((((..((((...((....))...)))).....)))))).))))))((((((...)))))).(((((.....)))))...)))))))...........((((....)))).)))).)))))).))
Thermodynamic Ensemble Prediction
..,(((,({.{{..,,,{|||(((,.(((((((...)))))))..}}}}}.||,...,||||.}||,,,,((((((((.(((({(((((((({{{(({((({((({((((.{.{|||.||{|||{|||{|{{||||||||,|}}.|}})},,...||||}}..|...}})}.},.,,....,..{,,{{.,,{((,,,,||,{,.}}|||.{|||{.(((((({.,,,{{..........|}.}}}})}})))}},}.(((((((((((.(((.....(((((((((((((..............((((.((,((......)}.}})}.))))......((((((((...(((((((..(((..((.....))..)))..((({...}))),.)))))))..((((.((....(((((...((((.....)))).))))).)).))))(((.(....).)))...))).))))))))))))))..))))))).))))).,,..(((....)))..|},......))))))...{((({{(((,,,,,,,,|||}.}|||}||{{|||||||}}|||||,,,,,,((({,..,,,,.....{(((((..(((,{{...,,.)))..)))))).,.||||||,.,})}}}.,,},,..}}})},))))))))).}|}|}}}}{{.{{{{||{{{|.,,,,|{{.,|||},(((((,,{{{||.||,((((.{(({{..,||,..,)),,.},,}}},,,)))))),}}}})){|||||,,,}}}))))|||||,....}})))}}}})))))}...,,......{{{{....}})).}}}}.}}}}}).)}

Transcripts

ID Sequence Length GC content
NM_000804.4 NCBI
AGAGCCUGGACCUACAGCGCUGUUGGUGGAGGUCCUGCCUCCAGGAAUA… 849 nt 0.5830
NM_001412270.1 NCBI
AGAGCCUGGACCUACAGCGCUGUUGGUGGAGGUCCUGCCUCCAGGAAUA… 975 nt 0.5867
Summary

This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Forensic Context

A study in humans identified ENST00000611028.2 as an mRNA diagnostic biomarker for acute myocardial infarction, showing it was upregulated in ST-elevation myocardial infarction patients compared to non-ST-elevation myocardial infarction patients with a fold change of 6.75 [Zhong et al. DOI:10.1097/MD.0000000000013066].