This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[provided by RefSeq, Sep 2009]
Forensic Context
A study in humans demonstrated that the FOXJ1 was identified as a member of the upper quartile gene coexpression modules significantly associated with lifetime alcohol consumption in postmortem prefrontal cortex, with prior validation in independent studies for alcohol consumption [Farris et al. DOI:10.1038/Mp.2014.159].