Basic Information

Symbol
FXYD2
RNA class
mRNA
Alias
FXYD Domain Containing Ion Transport Regulator 2 ATP1G1 Sodium/Potassium-Transporting ATPase Subunit Gamma Na(+)/K(+) ATPase Subunit Gamma Sodium Pump Gamma Chain MGC12372 HOMG2 ATPase, Na+/K+ Transporting, Gamma 1 Polypeptide FXYD Domain-Containing Ion Transport Regulator 2 Hypomagnesemia 2, Renal ATP1C
Location (GRCh38)
11:117800839-117828698
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001680.5
Sequence length
589.0 nt
GC content
0.5857

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-218.40 kcal/mol
Thermodynamic ensemble
Free energy: -227.78 kcal/mol
Frequency: 0.0000
Diversity: 188.66
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...........((((((((((((((((.(((.((((.((((((.(....)))))))((((((........)))))).(((....)))(((((.(((((.....(((((((((((((.....))))).......(((((....(((((.(((((((((.(.(((.....)))).))))))))).)))))....)))))(((((.((((.((....)).)))).)))))........((.(((((((.(((......)))(((.......((((((....((((((.....))))))...((((((((((((....)).))).)))))))..((((((((((............((((((((....(((((((((.(((........)))...)))).))))))))).))))((.....)).......(((((((((.((........))...)))))))))...((((......)))).))))))))))...))))))...)))...)))))))))))))))))...))))).)))))..)))))))..)))...(((....)))......)))))...))))))))...
Thermodynamic Ensemble Prediction
...........{(((((((((((({((,((..,(((,((({(({(((((((({,{{((({{{,,...,,,,)))))}||||,,||.,(((((,((({{|||,.((((((({({(((..,..})}}}.......{{(((.,,.,{(((.(((((((((.(.(((.....)))).))))))))).)))))}.},)})}){((((.((((.((....)).)))).))))),.....,.{(,{(((((,.,,{.....,|}|{{{|,{....,||,{{...||{(((({,...}}}}}|...((((((((((((....)),})).)))))))}.((((((((((............{{({(({{....({{{{|||{,|((,.,.....}}}...}))|,}}}}}}))).)))).,,,...}}},.....(((((((((.((........))...)))))))))...((((......)))).))))))))))...))))))}}}))).,})})))))}))))))}}}...||||}.}}||},{|},,,||..|)}...||,....,))}),.,}),,,,...))))))))...

Transcripts

ID Sequence Length GC content
NM_001680.5 NCBI
AGACACUCUCCAAAAAGCAGAGACAGCAGGAAGAGGGGAGUGGAGGCAG… 589 nt 0.5857
NM_021603.4 NCBI
ACUCUCCAUCCAGGCCCCAGGCAAGCAGCACCUCCCUGCUCUCCUGCAC… 593 nt 0.5970
Summary

This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]

Forensic Context

A study in humans demonstrated that the FXYD2 was identified as an mRNA marker for kidney tissue identification, functioning by modulating the activity of the Na,K-ATPase [Lindenbergh et al. DOI:10.1007/s00414-013-0895-7]. Subsequent research tested the FXYD2 as a potential urine-specific marker but found it exhibited limited sensitivity in that forensic application [van den Berge et al. DOI:10.1016/j.fsigen.2015.10.011].