This gene encodes the most abundant protein in human blood. This protein functions in the regulation of blood plasma colloid osmotic pressure and acts as a carrier protein for a wide range of endogenous molecules including hormones, fatty acids, and metabolites, as well as exogenous drugs. Additionally, this protein exhibits an esterase-like activity with broad substrate specificity. The encoded preproprotein is proteolytically processed to generate the mature protein. A peptide derived from this protein, EPI-X4, is an endogenous inhibitor of the CXCR4 chemokine receptor. [provided by RefSeq, Jul 2016]
Forensic Context
Human Serum Albumin (HSA) is identified as a protein marker for donor profiling and individual distinction, where it is the most abundant protein in the core urinary proteome and helps distinguish individuals [Alex et al. DOI:10.1016/j.scijus.2025.101320].