Basic Information

Symbol
GAST
RNA class
mRNA
Alias
Gastrin GAS Preprogastrin
Location (GRCh38)
17:41712331-41715969
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000805.5
Sequence length
465.0 nt
GC content
0.5892

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-168.90 kcal/mol
Thermodynamic ensemble
Free energy: -177.07 kcal/mol
Frequency: 0.0000
Diversity: 88.51
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....((.(((((((.(((((.((((..(((((((.((((((....((((.(((((.......))))).).))).))))))..))))).......)).)))).)))))..))).))))....((((((((((.((...(((((....((((((..(((((....))).((((..((....))..))))..))....))))))))))).)).(((((((((((.((......)).))..)))))).)))..(((((..((((.....))))..))))).)))))))))).(((((...((((((((.................(((..((.(((.((..((((...((.((.((.(((((...........))))))).))...))....).))).)))))))..))).....))))))))..)))))(((..((((((.............)))))).))).)).
Thermodynamic Ensemble Prediction
.,,,,({.(((((((.((((({({((,.(((((((.((((((....((((.(((((.......))))).).))).)))))}..))))).......)).)}))}}))))..)))}})))....((((((((((.((...(((((,,,{{((({(..{,{((....}}}.((((..((....))..))))..}},.,,))))))))))).)).((((((((({{,({......)}.))..)))))).)))..(((((..((((.....))))..))))).)))))))))).(((((.{.((((((((.........,....}}.{((..((.(((.((..((((...((.((.((,(((((.........,.))))))).))...))....).))).))))))),,))}.....)))))))).}))))){((..,{{{{{.............,})))),}}}.,,.

Transcripts

ID Sequence Length GC content
NM_000805.5 NCBI
AGAGACCUGAGAGGCACCAGGCCCAGCCGUGGCACCACACACCUCCCAG… 465 nt 0.5892
Summary

Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that serum levels of the GAST did not change after 6 or 12 Gy X-ray irradiation to the stomach, in contrast to increased levels of pepsinogen A and pepsinogen C, indicating its stability in this model of radiation-induced gastric injury [Chen et al. DOI:10.1177/1559325819886766].