Basic Information

Symbol
GCHFR
RNA class
mRNA
Alias
GTP Cyclohydrolase I Feedback Regulator GFRP GTP Cyclohydrolase I Feedback Regulatory Protein HsT16933 GTP Cyclohydrolase 1 Feedback Regulatory Protein P35
Location (GRCh38)
15:40764068-40767708
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005258.3
Sequence length
727.0 nt
GC content
0.6382

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-332.10 kcal/mol
Thermodynamic ensemble
Free energy: -343.07 kcal/mol
Frequency: 0.0000
Diversity: 218.55
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((.(((((......)))))..))).(((((((......)))))))...((((((((.((..((((((.((((.(.(((((....))).)))))))..))))))..)).))).)))))....((((((((....((((..((((.(((((.(((((((....(((((((..(((((..........(((((((((...)))).)))))(((.....((((((.((((.(((.....))).........((((((((((..((.((((((((((((..((..(.(((...(((((.((....)))))))))).).))..))).)))))).))).)))))).))))))...(((.(((..(((((....)))))..))).)))..((((((((((((......((((((((((......))))....))))))......))))...))))))))...)))).)))))))))...))))).))))))))))))))((((....))))........((((((((.....((((((.....)))).))))))))))..((((((((((((.((.((....((((((((....((....((((((((((...))))).....)))))..)).....)))))))))))).))))....)))))))))))))))))..)))).((...((....))...))((((((...........)))))))))))))).
Thermodynamic Ensemble Prediction
{(((..(((((({.{(({{.}|{{{((.(((((((......))))))).,.((((((((.((..((((((.((((.(.(((((....))).)))))))..))))))..)).))).)))))...(((((((((((.,,..((((((..((...{(.(,(((({...|}),)),).}}...}},.))))))..|.))))))).)))}{((.((((({{{.....,,.})))))).))}..............,,,,,,{(((.,.(,({{{{{{{{{{{.|||.,,}||,,}}|||,,.(({,{{||||||||}|,|.,|||))),}|||||,}}|,||||||,|}}}}}}}}|||,{((..{(({{,..,))))),,))),,},..|||{||||{(({,,,||.|{{{(((({{,,...,)))),...})))))}},,,,)))}...}}))))}).})))))).))))...,...(((((((.(((.{.(((((((((({{,((((((((.....(((((((({.,..{,((((.....)))),}))))))))){(((((,((...}).)))))}..,,})))))))..,,.,,.)))}})))))).,{|||.(((((((((((((((.((..((((....)))).(((((...((((({...,)))))))))).)).))))))}.,))))))))..,||||...........,))),))))))).,.

Transcripts

ID Sequence Length GC content
NM_005258.3 NCBI
AGAGCCGGAGUAACGGGACUCCCAGCUGCGCGUCGCAGUCCCGACGCGA… 727 nt 0.6382
Summary

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the GCHFR gene was upregulated in subcutaneous adipose tissue during short-term (0-5 month) weight loss in obese participants [Bollepalli et al. DOI:10.1038/ijo.2017.245].