Basic Information

Symbol
GNG3
RNA class
mRNA
Alias
G Protein Subunit Gamma 3 Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-3 Guanine Nucleotide Binding Protein (G Protein), Gamma 3 Guanine Nucleotide-Binding Protein Gamma-3 Subunit NBP Gamma-3 Heterotrimeric Guanine Nucleotide-Binding Protein 3D GNGT3 HG3D
Location (GRCh38)
11:62706400-62712083
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Sudden death from CNS diseases Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012202.5
Sequence length
864.0 nt
GC content
0.5602

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-269.60 kcal/mol
Thermodynamic ensemble
Free energy: -286.03 kcal/mol
Frequency: 0.0000
Diversity: 278.98
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((......(((.((.((((((((....(((.(((...((((((((.((.((.(((..(((((((.(((.(.(((((((..(((((.(((((((((.((((((((..((((((.((...((((.(.((.....)).).))))........((((((((((........((((...((.(((......))).))..)))))))..)))))))(((.......)))))..)))))).....)))))))).).).))))..(((.(((((((..(((...((((((.(.((((..((.(((((....((((.......))))...((((((((((((((((((((....((((...((((.............))))..)))).))))))((((((....)))))).........(((((....(((((..(((....)))((((((...))))))..((((......)))).....(((........)))................))))))))))....((((((((((((((..((((.(((((.....)))))...............))))..))).))))))...))))))))))))..)))))))..))))).))........((((.((.((..............)).)).)))).....((....(((((...(((((..((((..(((........)))))))..)).)))..)))))...))))))).)))))).....)))))))..))).))).....))).)))))..)))))))).))).).))))))))))).)).)))).))))))).)))...)))...))))).)).)))......)))).....
Thermodynamic Ensemble Prediction
.{(((.,....(((.((.((((((((....(((.(((...((((((((.((.((.((,.,((((((,((((.{,{{(((((,.(((((.(({(((({(.{{{{{{((..{{{{{{,((...{({|.{,{{,,..,}|,|.|||}...,,,..{{|||{|{{|,,......(((({,,({.(((,..{,.}}}.}}.,|||||||{,,,,,,||(((,{{,,{.},.,,..))))),.,{{{|}||||||.|{|.}}}},{(({.{{{||||..(((...((((((.(.(((({{(,{(((,,..,,({,,.....,,,,))},.|||||||{(({{{,((((((....((((...((((.............))))..)))).))))))((((((....)))))).......,,|||||...,(((({....,.,,,}||((((({...}))))),.((((......)))).,...,|,......,,},.....}}}}}}},,...}}))))))))}}}....|||||||||...{((.{.(((((.....)))))...))}.......,..}}}}.}))})))),}..|}))))}))))))}.}))}}}||}}}}}|,||,...,,,{((((.,,,((..............,)})).)))).....{{....(((((...{({{(..{{{|.|(((........)))))))..)).}}}..)))))...|||}|||,}))}}}.....,,}))}),,})),))),.,..})).))))).,)))))))).}}},).))))))))))).)).)))).))))))),)))...)}},,,))))).}}.)))....,.)))}.....

Transcripts

ID Sequence Length GC content
NM_012202.5 NCBI
CUUCUAGCAUCCUUCAUCCUUCAGGUACCAGCCAUCCAGACAGUGCUUG… 864 nt 0.5602
Summary

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]

Forensic Context

A study in human traumatic brain injury (TBI) patients identified GNG3 (G protein subunit gamma 3) as a differentially expressed mRNA biomarker appearing in the cholinergic synapse and dopaminergic synapse KEGG pathways [Yang et al. DOI:10.4103/1673-5374.247467].